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10.1111/j.1349-7006.1992.tb00090.x

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suck abstract from ncbi


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pmid1556004
      Jpn+J+Cancer+Res 1992 ; 83 (2 ): 226-31
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  • A comparison between argon-dye and excimer-dye laser for photodynamic effect in transplanted mouse tumor #MMPMID1556004
  • Okunaka T ; Kato H ; Konaka C ; Sakai H ; Kawabe H ; Aizawa K
  • Jpn J Cancer Res 1992[Feb]; 83 (2 ): 226-31 PMID1556004 show ga
  • Photodynamic therapy (PDT) utilizing a hematoporphyrin derivative (HpD) as a sensitizer has become a viable option for the local treatment of neoplastic disease. The argon-dye laser system is commonly used as a light source in this treatment modality. The excimer-dye laser, on the other hand, delivers high-energy red light in a pulsatile fashion. In this investigation, we treated BALB/c mice bearing mouse kidney sarcoma cell tumors with PDT using HpD at the dose of 5 mg/kg body weight as a photosensitizer and either a standard argon-dye laser or the pulsatile excimer-dye laser as the light source. At equal light energy doses (50 J/cm2), necrotic changes at depths averaging 4 mm from the tumor surface were obtained with the argon-dye laser (200 mW power output) while tumor necrosis at depths exceeding 15 mm from the tumor surface was obtained using the excimer-dye laser (6 mJ/pulse, 5 Hz). To determine the best conditions for photoirradiation with the excimer-dye laser, tumor-bearing mice were treated with different total light doses (10, 30 and 50 J/cm2), dose rates (1, 3 and 6 mJ/cm2), and frequencies (5, 15 and 50 Hz) of light exposure. Our results indicate that the optimal effects obtained with the excimer-dye laser are related to the total light dose used and the dose rate, but not to the frequency of light exposure.
  • |*Laser Therapy [MESH]
  • |Animals [MESH]
  • |Female [MESH]
  • |Hematoporphyrin Photoradiation/*methods [MESH]
  • |Kidney Neoplasms/*drug therapy [MESH]
  • |Mice [MESH]
  • |Mice, Inbred BALB C [MESH]


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