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1992 ; 83
(2
): 226-31
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A comparison between argon-dye and excimer-dye laser for photodynamic effect in
transplanted mouse tumor
#MMPMID1556004
Okunaka T
; Kato H
; Konaka C
; Sakai H
; Kawabe H
; Aizawa K
Jpn J Cancer Res
1992[Feb]; 83
(2
): 226-31
PMID1556004
show ga
Photodynamic therapy (PDT) utilizing a hematoporphyrin derivative (HpD) as a
sensitizer has become a viable option for the local treatment of neoplastic
disease. The argon-dye laser system is commonly used as a light source in this
treatment modality. The excimer-dye laser, on the other hand, delivers
high-energy red light in a pulsatile fashion. In this investigation, we treated
BALB/c mice bearing mouse kidney sarcoma cell tumors with PDT using HpD at the
dose of 5 mg/kg body weight as a photosensitizer and either a standard argon-dye
laser or the pulsatile excimer-dye laser as the light source. At equal light
energy doses (50 J/cm2), necrotic changes at depths averaging 4 mm from the tumor
surface were obtained with the argon-dye laser (200 mW power output) while tumor
necrosis at depths exceeding 15 mm from the tumor surface was obtained using the
excimer-dye laser (6 mJ/pulse, 5 Hz). To determine the best conditions for
photoirradiation with the excimer-dye laser, tumor-bearing mice were treated with
different total light doses (10, 30 and 50 J/cm2), dose rates (1, 3 and 6
mJ/cm2), and frequencies (5, 15 and 50 Hz) of light exposure. Our results
indicate that the optimal effects obtained with the excimer-dye laser are related
to the total light dose used and the dose rate, but not to the frequency of light
exposure.