Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41588-018-0059-2 http://scihub22266oqcxt.onion/10.1038/s41588-018-0059-2 C5918692!5918692 !29483656     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29483656 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2018 ; 50 (3 ): 381-389 Nephropedia Template TP {{tp|p=29483656 |t=2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection |pdf=|usr=}}{{29483656 }} gab.com Text Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=29483656 #FOAvip Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-scale genomic studies have begun to provide insights. We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through meta-analysis with existing data we identify 50 novel associated loci and 145 loci in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci. We also show for the first time that the common variant association signal is highly enriched among genes that are under strong selective pressures. These findings provide new insights into the biology and genetic architecture of schizophrenia, highlight the importance of mutation-intolerant genes and suggest a mechanism by which common risk variants persist in the population. Twit Text FOAVip Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=29483656 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29483656 #FOAvip English Wikipedia <ref>{{Cite pmid|29483656 }}</ref> Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection #MMPMID29483656 Pardiñas AF ; Holmans P ; Pocklington AJ ; Escott-Price V ; Ripke S ; Carrera N ; Legge SE ; Bishop S ; Cameron D ; Hamshere ML ; Han J ; Hubbard L ; Lynham A ; Mantripragada K ; Rees E ; MacCabe JH ; McCarroll SA ; Baune BT ; Breen G ; Byrne EM ; Dannlowski U ; Eley TC ; Hayward C ; Martin NG ; McIntosh AM ; Plomin R ; Porteous DJ ; Wray NR ; Caballero A ; Geschwind DH ; Huckins LM ; Ruderfer DM ; Santiago E ; Sklar P ; Stahl EA ; Won H ; Agerbo E ; Als TD ; Andreassen OA ; Bækvad-Hansen M ; Mortensen PB ; Pedersen CB ; Børglum AD ; Bybjerg-Grauholm J ; Djurovic S ; Durmishi N ; Pedersen MG ; Golimbet V ; Grove J ; Hougaard DM ; Mattheisen M ; Molden E ; Mors O ; Nordentoft M ; Pejovic-Milovancevic M ; Sigurdsson E ; Silagadze T ; Hansen CS ; Stefansson K ; Stefansson H ; Steinberg S ; Tosato S ; Werge T ; Collier DA ; Rujescu D ; Kirov G ; Owen MJ ; O'Donovan MC ; Walters JTR Nat Genet 2018[Mar]; 50 (3 ): 381-389 PMID29483656 show ga Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life and decreased life expectancy. Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-scale genomic studies have begun to provide insights. We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through meta-analysis with existing data we identify 50 novel associated loci and 145 loci in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci. We also show for the first time that the common variant association signal is highly enriched among genes that are under strong selective pressures. These findings provide new insights into the biology and genetic architecture of schizophrenia, highlight the importance of mutation-intolerant genes and suggest a mechanism by which common risk variants persist in the population. |*Polymorphism, Single Nucleotide [MESH] |*Selection, Genetic [MESH] |Alleles [MESH] |Case-Control Studies [MESH] |Gene Frequency [MESH] |Genes, Lethal/*genetics [MESH] |Genetic Loci [MESH] |Genetic Predisposition to Disease [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH] |Inheritance Patterns [MESH]Common schizophrenia alleles are enriched in mutation-intolerant genes(epmc).pdf DeepDyve Pubget Overpricing