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10.1016/j.jid.2016.03.018 http://scihub22266oqcxt.onion/10.1016/j.jid.2016.03.018 C5918687!5918687!27021406     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Invest+Dermatol 2016 ; 136 (7): 1355-63 Nephropedia Template TP {{tp|p=27021406|t=2016. Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone |pdf=|usr=}}{{27021406}} gab.com Text Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone JO: J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=27021406 #FOAvip Clinically, many nail disorders accompany bone deformities, but whether the two defects are causally related is under debate. To investigate the potential interactions between the two tissue types, we analyzed epithelial-specific ?-catenin deficient mice, in which nail differentiation is abrogated. These mice showed regression of not only the nail plate but also of the underlying digit bone. Characterization of these bone defects revealed active bone resorption, which is suppressed by Wnt activation in osteoblast and osteoclast precursors. Furthermore, we found that Wntless (Wls) expression, essential for Wnt ligand secretion, was lacking in the ?-catenin deficient nail epithelium and that genetic deletion of Wls in the nail epithelium led to the lack of Wnt activation in osteoblast and osteoclast precursors and subsequently led to defective regression of the underlying digit bone. Together, these data show epithelial Wnt ligands can ultimately regulate Wnt signaling in osteoblasts and osteoclast precursors, known to regulate bone homeostasis. These results reveal a critical role for the nail epithelium on the digit bone during homeostatic regeneration and show that Wnt/?-catenin signaling is critical for this interaction. Twit Text FOAVip Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone ????J Invest Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=27021406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27021406 #FOAvip English Wikipedia <ref>{{Cite pmid|27021406}}</ref> Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone #MMPMID27021406 Takeo M; Hale CS; Ito M J Invest Dermatol 2016[Jul]; 136 (7): 1355-63 PMID27021406show ga Clinically, many nail disorders accompany bone deformities, but whether the two defects are causally related is under debate. To investigate the potential interactions between the two tissue types, we analyzed epithelial-specific ?-catenin deficient mice, in which nail differentiation is abrogated. These mice showed regression of not only the nail plate but also of the underlying digit bone. Characterization of these bone defects revealed active bone resorption, which is suppressed by Wnt activation in osteoblast and osteoclast precursors. Furthermore, we found that Wntless (Wls) expression, essential for Wnt ligand secretion, was lacking in the ?-catenin deficient nail epithelium and that genetic deletion of Wls in the nail epithelium led to the lack of Wnt activation in osteoblast and osteoclast precursors and subsequently led to defective regression of the underlying digit bone. Together, these data show epithelial Wnt ligands can ultimately regulate Wnt signaling in osteoblasts and osteoclast precursors, known to regulate bone homeostasis. These results reveal a critical role for the nail epithelium on the digit bone during homeostatic regeneration and show that Wnt/?-catenin signaling is critical for this interaction. äEpithelium-derived Wnt ligands are essential for maintenance of underl(epmc).pdf DeepDyve Pubget Overpricing