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10.1111/j.1349-7006.1992.tb02360.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1992.tb02360.x C5918644!5918644!1544867     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 1992 ; 83 (1): 113-20 Nephropedia Template TP {{tp|p=1544867|t=1992. Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics |pdf=|usr=}}{{1544867}} gab.com Text Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1544867 #FOAvip The anticellular and antitumor activities of novel antitumor antibiotics, duocarmycins (DUMs), were examined against human and murine tumor cells. DUMs consist of live compounds, A, B1, B2, C1, and C2, which possess a pharmacophore similar to that of CC?1065, a previously isolated antibiotic. Among them, DUMA exhibited ultrapotent growth?inhibitory activity with an IC50 value of 6 pM against human uterine cervix carcinoma HeLa S3 cells. DUMA and DUMB1 also inhibited the growth of adriamycin (ADM)?resistant lines of human nasopharynx carcinoma KB cells and breast carcinoma MCF?7 cells as well as their sensitive lines. DUMs inhibited the growth of s.c.?inoculated murine tumors such as B16 melanoma, sarcoma 180, M5076 sarcoma and colon 26. DUMs were also significantly effective in increasing the lifespan of i.p.?inoculated B16 melanoma?bearing mice, although their effect was marginal against other i.p.?inoculated tumors. As a whole, DUMB1 exhibited superior activity to the other four compounds. DUMB1 rapidly inhibited the incorporation of [3H]?TdR into macromolecules of HeLa S3 cells as compared with that of [3H]UR or [3H]leucine. DNA strand breaks were detected in DUMB1 ?treated HeLa S3 cells by agarose gel electrophoresis with a contour?clamped homogeneous electric field apparatus. These results indicate that DUMs possess interesting biological activities as DNA?targeting antitumor antibiotics. Twit Text FOAVip Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1544867 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1544867 #FOAvip English Wikipedia <ref>{{Cite pmid|1544867}}</ref> Anticellular and Antitumor Activity of Duocarmycins, Novel Antitumor Antibiotics #MMPMID1544867 Gomi K; Kobayashi E; Miyoshi K; Ashizawa T; Okamoto A; Ogawa T; Katsumata S; Mihara A; Okabe M; Hirata T Jpn J Cancer Res 1992[Jan]; 83 (1): 113-20 PMID1544867show ga The anticellular and antitumor activities of novel antitumor antibiotics, duocarmycins (DUMs), were examined against human and murine tumor cells. DUMs consist of live compounds, A, B1, B2, C1, and C2, which possess a pharmacophore similar to that of CC?1065, a previously isolated antibiotic. Among them, DUMA exhibited ultrapotent growth?inhibitory activity with an IC50 value of 6 pM against human uterine cervix carcinoma HeLa S3 cells. DUMA and DUMB1 also inhibited the growth of adriamycin (ADM)?resistant lines of human nasopharynx carcinoma KB cells and breast carcinoma MCF?7 cells as well as their sensitive lines. DUMs inhibited the growth of s.c.?inoculated murine tumors such as B16 melanoma, sarcoma 180, M5076 sarcoma and colon 26. DUMs were also significantly effective in increasing the lifespan of i.p.?inoculated B16 melanoma?bearing mice, although their effect was marginal against other i.p.?inoculated tumors. As a whole, DUMB1 exhibited superior activity to the other four compounds. DUMB1 rapidly inhibited the incorporation of [3H]?TdR into macromolecules of HeLa S3 cells as compared with that of [3H]UR or [3H]leucine. DNA strand breaks were detected in DUMB1 ?treated HeLa S3 cells by agarose gel electrophoresis with a contour?clamped homogeneous electric field apparatus. These results indicate that DUMs possess interesting biological activities as DNA?targeting antitumor antibiotics. äAnticellular and Antitumor Activity of Duocarmycins, Novel Antitumor A(epmc).pdf DeepDyve Pubget Overpricing