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10.1111/j.1349-7006.1991.tb01929.x

http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1991.tb01929.x
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suck abstract from ncbi


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pmid1938601
      Jpn+J+Cancer+Res 1991 ; 82 (9 ): 969-73
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  • Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas #MMPMID1938601
  • Kuniyasu H ; Yoshida K ; Yokozaki H ; Yasui W ; Ito H ; Toge T ; Ciardiello F ; Persico MG ; Saeki T ; Salomon DS ; et al.
  • Jpn J Cancer Res 1991[Sep]; 82 (9 ): 969-73 PMID1938601 show ga
  • The expression of mRNA for cripto gene, a novel transforming gene of the epidermal growth factor family, was examined in 20 alimentary tract carcinoma cell lines, 60 surgically resected tumor tissues and their adjacent normal mucosas. Although the cripto mRNA was not detected in esophageal carcinomas or in normal mucosas, it was detected in gastric and colorectal carcinomas. In gastric carcinomas, 2.2 kb cripto mRNA was detected in one cell line, all the gastric carcinoma tissues and their adjacent normal mucosas. Of 23 gastric tumor tissues 8 (34.8%) exhibited a higher mRNA level than normal gastric mucosas. cripto mRNA was detected in 2 out of 6 colorectal carcinoma cell lines. Interestingly, 18 (81.8%) out of 22 colorectal carcinoma specimens expressed a higher level of cripto mRNA than that in normal mucosas. The level of the expression was higher than that in gastric carcinoma tissues. The expression was also correlated to tumor stage of colorectal carcinomas.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Aged, 80 and over [MESH]
  • |Colorectal Neoplasms/genetics [MESH]
  • |Epidermal Growth Factor/*genetics [MESH]
  • |Esophageal Neoplasms/genetics [MESH]
  • |Female [MESH]
  • |Gastric Mucosa/physiology [MESH]
  • |Gastrointestinal Neoplasms/*genetics [MESH]
  • |Gene Expression [MESH]
  • |Humans [MESH]
  • |Intestinal Mucosa/physiology [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |RNA, Messenger/genetics [MESH]


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