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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Jpn+J+Cancer+Res
1991 ; 82
(9
): 969-73
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English Wikipedia
Expression of cripto, a novel gene of the epidermal growth factor family, in
human gastrointestinal carcinomas
#MMPMID1938601
Kuniyasu H
; Yoshida K
; Yokozaki H
; Yasui W
; Ito H
; Toge T
; Ciardiello F
; Persico MG
; Saeki T
; Salomon DS
; et al.
Jpn J Cancer Res
1991[Sep]; 82
(9
): 969-73
PMID1938601
show ga
The expression of mRNA for cripto gene, a novel transforming gene of the
epidermal growth factor family, was examined in 20 alimentary tract carcinoma
cell lines, 60 surgically resected tumor tissues and their adjacent normal
mucosas. Although the cripto mRNA was not detected in esophageal carcinomas or in
normal mucosas, it was detected in gastric and colorectal carcinomas. In gastric
carcinomas, 2.2 kb cripto mRNA was detected in one cell line, all the gastric
carcinoma tissues and their adjacent normal mucosas. Of 23 gastric tumor tissues
8 (34.8%) exhibited a higher mRNA level than normal gastric mucosas. cripto mRNA
was detected in 2 out of 6 colorectal carcinoma cell lines. Interestingly, 18
(81.8%) out of 22 colorectal carcinoma specimens expressed a higher level of
cripto mRNA than that in normal mucosas. The level of the expression was higher
than that in gastric carcinoma tissues. The expression was also correlated to
tumor stage of colorectal carcinomas.