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10.1016/j.stemcr.2018.01.029

http://scihub22266oqcxt.onion/10.1016/j.stemcr.2018.01.029
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suck abstract from ncbi


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      Stem+Cell+Reports 2018 ; 10 (3 ): 933-941
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  • A Long-Term Follow-Up Study of Allogeneic Mesenchymal Stem/Stromal Cell Transplantation in Patients with Drug-Resistant Systemic Lupus Erythematosus #MMPMID29478901
  • Wang D ; Zhang H ; Liang J ; Wang H ; Hua B ; Feng X ; Gilkeson GS ; Farge D ; Shi S ; Sun L
  • Stem Cell Reports 2018[Mar]; 10 (3 ): 933-941 PMID29478901 show ga
  • Allogeneic mesenchymal stem/stromal cells (MSCs) have been widely studied as an alternative cell source for regenerative medicine. Here, we report a long-term follow-up study of allogeneic bone marrow and/or umbilical cord MSC transplantation (MSCT) in severe and drug-refractory systemic lupus erythematosus (SLE) patients. Eighty-one patients were enrolled, and the 5-year overall survival rate was 84% (68/81) after MSCT. At 5-year follow-up, 27% of patients (22/81) were in complete clinical remission and another 7% (6/81) were in partial clinical remission, with a 5-year disease remission rate of 34% (28/81). In total, 37 patients had achieved clinical remission and then 9 patients subsequently relapsed, with 5-year overall rate of relapse of 24% (9/37). SLE Disease Activity Index scores, serum albumin, complement C3, peripheral white blood cell, and platelet numbers, as well as proteinuria levels, continued to improve during the follow-up. Our results demonstrated that allogeneic MSCT is safe and resulted in long-term clinical remission in SLE patients.
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Child [MESH]
  • |Complement C3/metabolism [MESH]
  • |Cord Blood Stem Cell Transplantation/methods [MESH]
  • |Drug Resistance/*physiology [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Hematopoietic Stem Cell Transplantation/methods [MESH]
  • |Humans [MESH]
  • |Lupus Erythematosus, Systemic/metabolism/*pathology/surgery [MESH]
  • |Male [MESH]
  • |Mesenchymal Stem Cell Transplantation/methods [MESH]
  • |Mesenchymal Stem Cells/metabolism/*pathology [MESH]
  • |Middle Aged [MESH]
  • |Transplantation, Homologous/methods [MESH]


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