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2018 ; 10
(3
): 933-941
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A Long-Term Follow-Up Study of Allogeneic Mesenchymal Stem/Stromal Cell
Transplantation in Patients with Drug-Resistant Systemic Lupus Erythematosus
#MMPMID29478901
Wang D
; Zhang H
; Liang J
; Wang H
; Hua B
; Feng X
; Gilkeson GS
; Farge D
; Shi S
; Sun L
Stem Cell Reports
2018[Mar]; 10
(3
): 933-941
PMID29478901
show ga
Allogeneic mesenchymal stem/stromal cells (MSCs) have been widely studied as an
alternative cell source for regenerative medicine. Here, we report a long-term
follow-up study of allogeneic bone marrow and/or umbilical cord MSC
transplantation (MSCT) in severe and drug-refractory systemic lupus erythematosus
(SLE) patients. Eighty-one patients were enrolled, and the 5-year overall
survival rate was 84% (68/81) after MSCT. At 5-year follow-up, 27% of patients
(22/81) were in complete clinical remission and another 7% (6/81) were in partial
clinical remission, with a 5-year disease remission rate of 34% (28/81). In
total, 37 patients had achieved clinical remission and then 9 patients
subsequently relapsed, with 5-year overall rate of relapse of 24% (9/37). SLE
Disease Activity Index scores, serum albumin, complement C3, peripheral white
blood cell, and platelet numbers, as well as proteinuria levels, continued to
improve during the follow-up. Our results demonstrated that allogeneic MSCT is
safe and resulted in long-term clinical remission in SLE patients.