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10.1111/j.1349-7006.1991.tb01880.x

http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1991.tb01880.x
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C5918476!5918476 !1905698
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suck abstract from ncbi


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pmid1905698
      Jpn+J+Cancer+Res 1991 ; 82 (5 ): 511-7
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  • Induction of transplantable tumors by repeated subcutaneous injections of natural and synthetic vitamin E in mice and rats #MMPMID1905698
  • Nitta Y ; Kamiya K ; Tanimoto M ; Sadamoto S ; Niwa O ; Yokoro K
  • Jpn J Cancer Res 1991[May]; 82 (5 ): 511-7 PMID1905698 show ga
  • Natural vitamin E and synthetic vitamin E (dl-alpha-tocopheryl acetate) were tested for their tumorigenicity in rodents. Transplantable tumors, at the site of injection, were induced by repeated injections of these compounds in two strains of mice, NFS/N and C57BL/6N x C3H/He F1, and in a strain of rats, Fischer 344. Natural vitamin E was tumorigenic in both strains of female mice only when injected with soya oil. In contrast, dl-alpha-tocopheryl acetate alone was capable of inducing tumors in Fischer 344 rats. Only one out of 5 male NFS/N mice given dl-alpha-tocopheryl acetate developed a tumor. Therefore, Fischer 344 rats were more susceptible to tumor formation by dl-alpha-tocopheryl acetate than NFS/N mice. dl-alpha-Tocopheryl acetate with soya oil or with palm oil also resulted in the formation of transplantable tumors in NFS/N mice and Fischer 344 rats. There was no difference in the tumor incidence between mice treated with dl-alpha-tocopheryl acetate alone and dl-alpha-tocopheryl acetate plus soya oil or palm oil. However, in rats, the incidence was lower for a group treated with dl-alpha-tocopheryl acetate plus palm oil than for those with dl-alpha-tocopheryl acetate alone and with dl-alpha-tocopheryl acetate plus soya oil.
  • |*alpha-Tocopherol/*analogs & derivatives [MESH]
  • |Animals [MESH]
  • |Fibrosarcoma/*chemically induced/genetics/pathology [MESH]
  • |Gene Amplification [MESH]
  • |Genes, myc [MESH]
  • |Injections, Subcutaneous [MESH]
  • |Mice [MESH]
  • |Mice, Inbred Strains [MESH]
  • |Neoplasm Transplantation [MESH]
  • |Palm Oil [MESH]
  • |Plant Oils/administration & dosage [MESH]
  • |Rats [MESH]
  • |Rats, Inbred F344 [MESH]
  • |Soft Tissue Neoplasms/*chemically induced/genetics/pathology [MESH]
  • |Soybean Oil/administration & dosage [MESH]
  • |Tocopherols [MESH]


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