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1991 ; 82
(5
): 511-7
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English Wikipedia
Induction of transplantable tumors by repeated subcutaneous injections of natural
and synthetic vitamin E in mice and rats
#MMPMID1905698
Nitta Y
; Kamiya K
; Tanimoto M
; Sadamoto S
; Niwa O
; Yokoro K
Jpn J Cancer Res
1991[May]; 82
(5
): 511-7
PMID1905698
show ga
Natural vitamin E and synthetic vitamin E (dl-alpha-tocopheryl acetate) were
tested for their tumorigenicity in rodents. Transplantable tumors, at the site of
injection, were induced by repeated injections of these compounds in two strains
of mice, NFS/N and C57BL/6N x C3H/He F1, and in a strain of rats, Fischer 344.
Natural vitamin E was tumorigenic in both strains of female mice only when
injected with soya oil. In contrast, dl-alpha-tocopheryl acetate alone was
capable of inducing tumors in Fischer 344 rats. Only one out of 5 male NFS/N mice
given dl-alpha-tocopheryl acetate developed a tumor. Therefore, Fischer 344 rats
were more susceptible to tumor formation by dl-alpha-tocopheryl acetate than
NFS/N mice. dl-alpha-Tocopheryl acetate with soya oil or with palm oil also
resulted in the formation of transplantable tumors in NFS/N mice and Fischer 344
rats. There was no difference in the tumor incidence between mice treated with
dl-alpha-tocopheryl acetate alone and dl-alpha-tocopheryl acetate plus soya oil
or palm oil. However, in rats, the incidence was lower for a group treated with
dl-alpha-tocopheryl acetate plus palm oil than for those with dl-alpha-tocopheryl
acetate alone and with dl-alpha-tocopheryl acetate plus soya oil.