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10.1111/j.1349-7006.1991.tb01869.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1991.tb01869.x C5918446!5918446 !1904424     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1904424 &cmd=llinks): Failed to open stream: HTTP request failed! 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T cell receptor-independent cell-mediated cytotoxicity by nude mouse lymphokine-activated killer cells |pdf=|usr=}}{{1904424 }} gab.com Text T cell receptor-independent cell-mediated cytotoxicity by nude mouse lymphokine-activated killer cells JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1904424 #FOAvip Lymphokine-activated killer (LAK) cells, which can lyse a variety of tumor cells, can be induced from both normal and athymic nude mouse spleen cells by culture with high doses of recombinant interleukin 2 (rIL-2). LAK cells generated from nude mouse spleen cells (Nude-LAK cells) express just Thy 1.2 antigen, but not CD4 and CD8 antigens. Nude-LAK cells express neither T3 molecule, T cell receptor (TCR) alpha beta nor TCR gamma delta on their cell surface. The lack of TCR expression on Nude-LAK cells was confirmed by the results of northern blot analysis. LAK cells generated from normal mouse spleen cells (Nor-LAK) express TCR alpha, beta transcripts, while Nude-LAK cells express only sterile TCR beta transcript, but not TCR alpha transcript. TCR gamma delta transcripts were scarcely detected in both Nor-LAK cells and Nude-LAK cells. Thus, it is strongly suggested that Nude-LAK cells can recognize and lyse tumor cells by TCR-independent mechanisms. Monoclonal antibody against lymphocyte function-associated antigen (LFA-1) molecule can block the cytotoxicity of Nude-LAK cells, indicating an important role of such accessory molecules in Nude-LAK cell-mediated cytotoxicity. Twit Text FOAVip T cell receptor-independent cell-mediated cytotoxicity by nude mouse lymphokine-activated killer cells ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1904424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1904424 #FOAvip English Wikipedia <ref>{{Cite pmid|1904424 }}</ref> T cell receptor-independent cell-mediated cytotoxicity by nude mouse lymphokine-activated killer cells #MMPMID1904424 Nishimura T ; Togashi Y ; Wakamiya N ; Hashimoto Y ; Yagita H ; Okumura K ; Habu S Jpn J Cancer Res 1991[Apr]; 82 (4 ): 448-55 PMID1904424 show ga Lymphokine-activated killer (LAK) cells, which can lyse a variety of tumor cells, can be induced from both normal and athymic nude mouse spleen cells by culture with high doses of recombinant interleukin 2 (rIL-2). LAK cells generated from nude mouse spleen cells (Nude-LAK cells) express just Thy 1.2 antigen, but not CD4 and CD8 antigens. Nude-LAK cells express neither T3 molecule, T cell receptor (TCR) alpha beta nor TCR gamma delta on their cell surface. The lack of TCR expression on Nude-LAK cells was confirmed by the results of northern blot analysis. LAK cells generated from normal mouse spleen cells (Nor-LAK) express TCR alpha, beta transcripts, while Nude-LAK cells express only sterile TCR beta transcript, but not TCR alpha transcript. TCR gamma delta transcripts were scarcely detected in both Nor-LAK cells and Nude-LAK cells. Thus, it is strongly suggested that Nude-LAK cells can recognize and lyse tumor cells by TCR-independent mechanisms. Monoclonal antibody against lymphocyte function-associated antigen (LFA-1) molecule can block the cytotoxicity of Nude-LAK cells, indicating an important role of such accessory molecules in Nude-LAK cell-mediated cytotoxicity. |Animals [MESH] |Antibodies, Monoclonal [MESH] |Antigens, Differentiation/analysis [MESH] |Antigens, Neoplasm [MESH] |Blotting, Northern [MESH] |Cell Separation [MESH] |DNA Probes [MESH] |Flow Cytometry [MESH] |Immunity, Cellular/*immunology [MESH] |Interleukin-2/pharmacology [MESH] |Lymphocyte Function-Associated Antigen-1/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Monocytes, Activated Killer/*immunology [MESH] |Receptors, Antigen, T-Cell/*immunology [MESH] |Recombinant Proteins/pharmacology [MESH] |T-Lymphocytes, Cytotoxic/*immunology [MESH]T cell receptor-independent cell-mediated cytotoxicity by nude mouse (epmc).pdf DeepDyve Pubget Overpricing