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10.1111/j.1349-7006.1991.tb01871.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1991.tb01871.x C5918439!5918439 !1904426     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1904426 &cmd=llinks): Failed to open stream: HTTP request failed! 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Augmentation by tumor necrosis factor alpha of the systemic therapeutic effect of lymphokine-activated killer cells in adoptive immunotherapy of murine tumor |pdf=|usr=}}{{1904426 }} gab.com Text Augmentation by tumor necrosis factor alpha of the systemic therapeutic effect of lymphokine-activated killer cells in adoptive immunotherapy of murine tumor JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1904426 #FOAvip The therapeutic effect of a combined modality of lymphokine-activated killer (LAK) cells and tumor necrosis factor alpha (TNF alpha) on MBL-2 tumor in C57BL/6 mice was studied. Murine LAK cells induced from splenocytes by interleukin 2 (IL2) could lyse MBL-2 target cells in vitro. but no enhancement of the LAK activity was found by the treatment of LAK cells with TNF alpha in vitro. However, the treatment of MBL-2 with TNF alpha enhanced the sensitivity to LAK cells. Moreover, administration of TNF alpha to mice bearing solid MBL-2 tumor led to increased tumor vascular permeability within 1 h, and resulted in the enhanced accumulation of systemically transferred LAK cells in tumor tissue. Based on these results, we treated MBL-2-bearing mice with TNF alpha and then with LAK cells 1 h later. No therapeutic effect was observed when tumor-bearing mice were treated with TNF alpha alone or LAK cells plus IL2. However, adoptive immunotherapy using LAK cells and TNF alpha had therapeutic effects, i.e., growth inhibition of tumor nodules and prolongation of survival. These results indicated that appropriately timed pretreatment of tumor-bearing mice with TNF alpha augmented the anti-tumor efficacy of LAK cells. Twit Text FOAVip Augmentation by tumor necrosis factor alpha of the systemic therapeutic effect of lymphokine-activated killer cells in adoptive immunotherapy of murine tumor ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=1904426 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1904426 #FOAvip English Wikipedia <ref>{{Cite pmid|1904426 }}</ref> Augmentation by tumor necrosis factor alpha of the systemic therapeutic effect of lymphokine-activated killer cells in adoptive immunotherapy of murine tumor #MMPMID1904426 Kato K ; Tanabe T ; Agatsuma T ; Suzuki S ; Nitanai H ; Hashimoto Y Jpn J Cancer Res 1991[Apr]; 82 (4 ): 464-9 PMID1904426 show ga The therapeutic effect of a combined modality of lymphokine-activated killer (LAK) cells and tumor necrosis factor alpha (TNF alpha) on MBL-2 tumor in C57BL/6 mice was studied. Murine LAK cells induced from splenocytes by interleukin 2 (IL2) could lyse MBL-2 target cells in vitro. but no enhancement of the LAK activity was found by the treatment of LAK cells with TNF alpha in vitro. However, the treatment of MBL-2 with TNF alpha enhanced the sensitivity to LAK cells. Moreover, administration of TNF alpha to mice bearing solid MBL-2 tumor led to increased tumor vascular permeability within 1 h, and resulted in the enhanced accumulation of systemically transferred LAK cells in tumor tissue. Based on these results, we treated MBL-2-bearing mice with TNF alpha and then with LAK cells 1 h later. No therapeutic effect was observed when tumor-bearing mice were treated with TNF alpha alone or LAK cells plus IL2. However, adoptive immunotherapy using LAK cells and TNF alpha had therapeutic effects, i.e., growth inhibition of tumor nodules and prolongation of survival. These results indicated that appropriately timed pretreatment of tumor-bearing mice with TNF alpha augmented the anti-tumor efficacy of LAK cells. |*Immunotherapy, Adoptive [MESH] |Animals [MESH] |Capillary Permeability [MESH] |Cell Division/drug effects [MESH] |Combined Modality Therapy [MESH] |Cytotoxicity, Immunologic [MESH] |Interleukin-2/pharmacology [MESH] |Lymphoma, Non-Hodgkin/*therapy [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Moloney murine leukemia virus [MESH] |Monocytes, Activated Killer/*immunology [MESH]Augmentation by tumor necrosis factor alpha of the systemic therapeuti(epmc).pdf DeepDyve Pubget Overpricing