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10.1111/j.1349-7006.1991.tb01775.x

http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1991.tb01775.x
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suck abstract from ncbi


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pmid1752776
      Jpn+J+Cancer+Res 1991 ; 82 (11 ): 1178-83
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  • Transformation of CD8+ T-cells producing a strong cytopathic effect on CD4+ T-cells through syncytium formation by HTLV-II #MMPMID1752776
  • Miyamoto K ; Kamiya T ; Minowada J ; Tomita N ; Kitajima K
  • Jpn J Cancer Res 1991[Nov]; 82 (11 ): 1178-83 PMID1752776 show ga
  • Human T-cell leukemia virus type II (HTLV-II) is thought to play an important role in the development of CD8+ T-cell malignancies resembling hairy cell leukemia. In this study, dramatic cytopathic effects characterized by syncytium formation in various CD4+ T-cell lines were observed upon their cocultivation with HTLV-II infected T-cells. The HTLV-II infected T-cells, however, did not die as a result of syncytium formation. HTLV-II also transformed CD4+ T-cells and CD8+ T-cells at various coculture ratios. Furthermore, sera from anti-HTLV-II antibody-positive specific carriers inhibited syncytium formation in the CD4+ T-cells. These results suggest that HTLV-II infection may contribute to the pathogenesis of associated CD8+ T-cell malignancies.
  • |*Lymphocyte Activation [MESH]
  • |Adult [MESH]
  • |CD4 Antigens/*immunology [MESH]
  • |CD8 Antigens/*immunology [MESH]
  • |Cell Line [MESH]
  • |Cells, Cultured [MESH]
  • |Cytotoxicity, Immunologic [MESH]
  • |Female [MESH]
  • |Giant Cells/*immunology [MESH]
  • |Human T-lymphotropic virus 2/*immunology/isolation & purification [MESH]
  • |Humans [MESH]
  • |Infant [MESH]
  • |Kinetics [MESH]
  • |Male [MESH]


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