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10.1111/j.1349-7006.1990.tb02584.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1990.tb02584.x C5918044!5918044 !2114394     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=2114394 &cmd=llinks): Failed to open stream: HTTP request failed! 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Combination treatment with irritant and recombinant interleukin 2 in the peritoneal cavity for evoking effective anti-tumor activity: generation of lymphokine-activated killer cells and tumor-specific killer cells |pdf=|usr=}}{{2114394 }} gab.com Text Combination treatment with irritant and recombinant interleukin 2 in the peritoneal cavity for evoking effective anti-tumor activity: generation of lymphokine-activated killer cells and tumor-specific killer cells JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2114394 #FOAvip Meth A sarcoma, growing in the subcutaneous tissue of syngeneic BALB/c mice, regressed completely after an intraperitoneal (ip) injection of proteose peptone (PP) (on day 6) followed by 2 ip administrations (on days 7 and 8) of human recombinant interleukin-2 (IL-2, 25 micrograms/day), whereas one such treatment alone had little effect on the tumor growth. While this combination treatment was effective in anti-asialo GM1 antibody-treated mice, no such effect was noted in T cell-depleted ATXFL (thymectomized, irradiated and fetal liver cell-reconstituted) mice. These results show that T cells are mainly responsible for this antitumor effect. Treatment with a combination of PP and IL-2, but not with either PP or IL-2 alone, resulted in a marked increase in the T cell population in the peritoneal cavity after the treatment. At an early stage after the combination treatment, both peritoneal exudate cells (PEC) and spleen cells exhibited killing activity with a promiscuous specificity. However, at a later stage, 7 days after the treatment, Meth A-specific killer activity was observed in both PEC and the spleen. Meth A rechallenge was rejected by the mice in which the tumor had regressed, but the antigenically different Meth 1 was accepted by them. A similar result was obtained in Winn's neutralization test. These results suggest that this combination treatment, which is effective in the generation of lymphokine-activated killer cells in the peritoneal cavity, finally resulted in the induction of tumor-specific killer cells in the periphery. These results clearly show the anti-tumor efficacy of combination treatment with PP and rIL-2. Twit Text FOAVip Combination treatment with irritant and recombinant interleukin 2 in the peritoneal cavity for evoking effective anti-tumor activity: generation of lymphokine-activated killer cells and tumor-specific killer cells ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2114394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2114394 #FOAvip English Wikipedia <ref>{{Cite pmid|2114394 }}</ref> Combination treatment with irritant and recombinant interleukin 2 in the peritoneal cavity for evoking effective anti-tumor activity: generation of lymphokine-activated killer cells and tumor-specific killer cells #MMPMID2114394 Uchida H ; Taniguchi K ; Nomoto K Jpn J Cancer Res 1990[Apr]; 81 (4 ): 416-24 PMID2114394 show ga Meth A sarcoma, growing in the subcutaneous tissue of syngeneic BALB/c mice, regressed completely after an intraperitoneal (ip) injection of proteose peptone (PP) (on day 6) followed by 2 ip administrations (on days 7 and 8) of human recombinant interleukin-2 (IL-2, 25 micrograms/day), whereas one such treatment alone had little effect on the tumor growth. While this combination treatment was effective in anti-asialo GM1 antibody-treated mice, no such effect was noted in T cell-depleted ATXFL (thymectomized, irradiated and fetal liver cell-reconstituted) mice. These results show that T cells are mainly responsible for this antitumor effect. Treatment with a combination of PP and IL-2, but not with either PP or IL-2 alone, resulted in a marked increase in the T cell population in the peritoneal cavity after the treatment. At an early stage after the combination treatment, both peritoneal exudate cells (PEC) and spleen cells exhibited killing activity with a promiscuous specificity. However, at a later stage, 7 days after the treatment, Meth A-specific killer activity was observed in both PEC and the spleen. Meth A rechallenge was rejected by the mice in which the tumor had regressed, but the antigenically different Meth 1 was accepted by them. A similar result was obtained in Winn's neutralization test. These results suggest that this combination treatment, which is effective in the generation of lymphokine-activated killer cells in the peritoneal cavity, finally resulted in the induction of tumor-specific killer cells in the periphery. These results clearly show the anti-tumor efficacy of combination treatment with PP and rIL-2. |Adjuvants, Immunologic/pharmacology [MESH] |Animals [MESH] |Caseins/*therapeutic use [MESH] |Cell Division [MESH] |Cytotoxicity, Immunologic [MESH] |Drug Therapy, Combination [MESH] |Female [MESH] |Injections, Intraperitoneal [MESH] |Injections, Subcutaneous [MESH] |Interleukin-2/administration & dosage/*therapeutic use [MESH] |Killer Cells, Lymphokine-Activated/physiology [MESH] |Killer Cells, Natural/physiology [MESH] |Methylcholanthrene [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Peptide Fragments/*therapeutic use [MESH] |Peritoneal Cavity/cytology [MESH] |Recombinant Proteins/administration & dosage/therapeutic use [MESH]Combination treatment with irritant and recombinant interleukin 2 in t(epmc).pdf DeepDyve Pubget Overpricing