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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Jpn+J+Cancer+Res 1990 ; 81 (3): 216-9 Nephropedia Template TP
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Modulation of c?myc Expression by Transforming Growth Factor ?1 in Human Hepatoma Cell Lines #MMPMID2161812
Ito N; Kawata S; Tamura S; Takaishi K; Saitoh R; Tarui S
Jpn J Cancer Res 1990[Mar]; 81 (3): 216-9 PMID2161812show ga
The effects of transforming growth factor ?1 (TGF??1) on cell proliferation of human hepatoma cell lines, PLC/PRF/5 and Mahlavu, were investigated under serum?free conditions. DNA synthesis was strongly inhibited in the PLC/PRF/5 cells by addition of TGF??1 (0.5 to 4.0 ng/ml), but remained unchanged in the Mahlavu cells. Also the expression of c?myc mRNA was suppressed by the addition of TGF??1 in the PLC/PRF/5 cells but not in the Mahlavu cells. These results indicate that TGF??1 might regulate cell growth, in part, by modulating c?myc expression, although there is no direct proof that c?myc expression is really relevant to DNA synthesis mediated by TGF??1.