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10.1111/j.1349-7006.1989.tb01658.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1989.tb01658.x C5917937!5917937 !2516849     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\2516849 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Jpn+J+Cancer+Res 1989 ; 80 (12 ): 1220-7 Nephropedia Template TP {{tp|p=2516849 |t=1989. Lymphokine-activated killer induction and its regulation by macrophages in malignant pleural effusions |pdf=|usr=}}{{2516849 }} gab.com Text Lymphokine-activated killer induction and its regulation by macrophages in malignant pleural effusions JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2516849 #FOAvip Mononuclear cells (MNC) from pleural effusions and peripheral blood of 18 patients with primary lung cancer with malignant pleural effusion were studied. Pleural and blood MNC generated lymphokine-activated killer (LAK) activity similarly when cultured for 4 days with an optimal concentration of interleukin 2 (IL-2). Highly purified lymphocytes (greater than 98%) and monocyte-macrophages (greater than 90%) were isolated by discontinuous Percoll gradient centrifugation from pleural and blood MNC. Pleural macrophages, as well as blood monocytes, showed significant augmenting effects on in vitro LAK cell induction from pleural and blood lymphocytes by IL-2. During daily intrapleural administration of IL-2, significant induction of LAK activity in vivo was observed after 3 days, but then this LAK activity in pleural MNC decreased almost to zero by day 15. Daily injections of IL-2 resulted in reduction in the up-regulation of LAK induction by pleural macrophages and also in increases in the levels of soluble IL-2 receptors in pleural effusions. These findings indicate that in vivo LAK induction of lymphocytes in malignant effusions by IL-2 may be regulated by macrophages in the effusions. Twit Text FOAVip Lymphokine-activated killer induction and its regulation by macrophages in malignant pleural effusions ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2516849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2516849 #FOAvip English Wikipedia <ref>{{Cite pmid|2516849 }}</ref> Lymphokine-activated killer induction and its regulation by macrophages in malignant pleural effusions #MMPMID2516849 Yanagawa H ; Sone S ; Nii A ; Fukuta K ; Nakanishi M ; Maeda K ; Honda M ; Ogura T Jpn J Cancer Res 1989[Dec]; 80 (12 ): 1220-7 PMID2516849 show ga Mononuclear cells (MNC) from pleural effusions and peripheral blood of 18 patients with primary lung cancer with malignant pleural effusion were studied. Pleural and blood MNC generated lymphokine-activated killer (LAK) activity similarly when cultured for 4 days with an optimal concentration of interleukin 2 (IL-2). Highly purified lymphocytes (greater than 98%) and monocyte-macrophages (greater than 90%) were isolated by discontinuous Percoll gradient centrifugation from pleural and blood MNC. Pleural macrophages, as well as blood monocytes, showed significant augmenting effects on in vitro LAK cell induction from pleural and blood lymphocytes by IL-2. During daily intrapleural administration of IL-2, significant induction of LAK activity in vivo was observed after 3 days, but then this LAK activity in pleural MNC decreased almost to zero by day 15. Daily injections of IL-2 resulted in reduction in the up-regulation of LAK induction by pleural macrophages and also in increases in the levels of soluble IL-2 receptors in pleural effusions. These findings indicate that in vivo LAK induction of lymphocytes in malignant effusions by IL-2 may be regulated by macrophages in the effusions. |Aged [MESH] |Cytotoxicity, Immunologic [MESH] |Humans [MESH] |Interleukin-2/administration & dosage/pharmacology [MESH] |Killer Cells, Lymphokine-Activated/*immunology [MESH] |Lung Neoplasms/*immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Macrophages/*immunology [MESH] |Middle Aged [MESH] |Monocytes/*immunology [MESH]Lymphokine-activated killer induction and its regulation by macrophage(epmc).pdf DeepDyve Pubget Overpricing