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10.1111/j.1349-7006.1989.tb01648.x

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suck abstract from ncbi


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pmid2516844
      Jpn+J+Cancer+Res 1989 ; 80 (12 ): 1161-4
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  • In vivo antitumor mechanism of natural human tumor necrosis factor involving a T cell-mediated immunological route #MMPMID2516844
  • Asami T ; Imai M ; Tanaka Y ; Hosaka Y ; Kato K ; Nakamura N ; Horisawa Y ; Ashida Y ; Kanamori T ; Nobuhara M ; et al.
  • Jpn J Cancer Res 1989[Dec]; 80 (12 ): 1161-4 PMID2516844 show ga
  • We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n-TNF) isolated from a culture of human leukemic B cell line (BALL-1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n-TNF on Meth A sarcoma implanted in BALB/c mice pretreated with monoclonal antibody against T cell-specific surface antigen (Thy-1) was significantly diminished. Furthermore, when BALB/c mice were treated with T cell subset-specific monoclonal antibodies, anti-L3T4 or anti-Lyt-2.2, the antitumor effect of n-TNF on Meth A sarcoma was significantly reduced. Therefore, it was suggested that the in vivo antitumor mechanism of n-TNF might involve a T cell-mediated immunological route.
  • |Animals [MESH]
  • |Humans [MESH]
  • |Mice [MESH]
  • |Mice, Inbred BALB C [MESH]
  • |Neoplasm Transplantation [MESH]
  • |Sarcoma, Experimental/*drug therapy/immunology [MESH]
  • |T-Lymphocytes/*immunology [MESH]
  • |Tumor Cells, Cultured [MESH]


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