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1989 ; 80
(12
): 1161-4
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In vivo antitumor mechanism of natural human tumor necrosis factor involving a T
cell-mediated immunological route
#MMPMID2516844
Asami T
; Imai M
; Tanaka Y
; Hosaka Y
; Kato K
; Nakamura N
; Horisawa Y
; Ashida Y
; Kanamori T
; Nobuhara M
; et al.
Jpn J Cancer Res
1989[Dec]; 80
(12
): 1161-4
PMID2516844
show ga
We have investigated the in vivo antitumor mechanism of natural human tumor
necrosis factor (n-TNF) isolated from a culture of human leukemic B cell line
(BALL-1), especially its action as an immunomodulator, and found that the in vivo
antitumor effect of n-TNF on Meth A sarcoma implanted in BALB/c mice pretreated
with monoclonal antibody against T cell-specific surface antigen (Thy-1) was
significantly diminished. Furthermore, when BALB/c mice were treated with T cell
subset-specific monoclonal antibodies, anti-L3T4 or anti-Lyt-2.2, the antitumor
effect of n-TNF on Meth A sarcoma was significantly reduced. Therefore, it was
suggested that the in vivo antitumor mechanism of n-TNF might involve a T
cell-mediated immunological route.