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10.1111/j.1349-7006.1989.tb02297.x

http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1989.tb02297.x
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suck abstract from ncbi


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pmid2498257
      Jpn+J+Cancer+Res 1989 ; 80 (3 ): 228-32
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  • Inhibitory action of transforming growth factor-beta on induction of differentiation of myeloid leukemia cells #MMPMID2498257
  • Okabe-Kado J ; Honma Y ; Hayashi M ; Hozumi M
  • Jpn J Cancer Res 1989[Mar]; 80 (3 ): 228-32 PMID2498257 show ga
  • The effect of transforming growth factor-beta (TGF-beta) on induction of differentiation of mouse myeloid leukemia M1 cells was investigated. TGF-beta 1 induced adherence of M1 cells to plastic dishes and inhibited their proliferation. However, it did not induce differentiation-associated properties, such as phagocytic activity, lysozyme activity or morphological maturation. TGF-beta 1 also caused dose-dependent inhibition of dexamethasone-induced differentiation of M1 cells. The inhibitory activity of TGF-beta 1 was 20 times that of TGF-beta 2 on M1 cells. These results suggest that TGF-beta 1 inhibits proliferation and dexamethasone-induced differentiation of M1 cells by interacting with receptors that can distinguish between TGF-beta 1 and TGF-beta 2. TGF-beta 1 had a much lower inhibitory effect on the growth of a variant M1 cell clone, which was resistant to differentiation inducers, and it did not induce adherence of the resistant M1 cells.
  • |Animals [MESH]
  • |Cell Adhesion/drug effects [MESH]
  • |Cell Differentiation/drug effects [MESH]
  • |Cell Division/drug effects [MESH]
  • |Dexamethasone/pharmacology [MESH]
  • |Leukemia, Myeloid/*pathology [MESH]
  • |Mice [MESH]
  • |Muramidase/metabolism [MESH]
  • |Phagocytosis/drug effects [MESH]
  • |Transforming Growth Factors/*pharmacology [MESH]


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