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1989 ; 80
(3
): 228-32
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Inhibitory action of transforming growth factor-beta on induction of
differentiation of myeloid leukemia cells
#MMPMID2498257
Okabe-Kado J
; Honma Y
; Hayashi M
; Hozumi M
Jpn J Cancer Res
1989[Mar]; 80
(3
): 228-32
PMID2498257
show ga
The effect of transforming growth factor-beta (TGF-beta) on induction of
differentiation of mouse myeloid leukemia M1 cells was investigated. TGF-beta 1
induced adherence of M1 cells to plastic dishes and inhibited their
proliferation. However, it did not induce differentiation-associated properties,
such as phagocytic activity, lysozyme activity or morphological maturation.
TGF-beta 1 also caused dose-dependent inhibition of dexamethasone-induced
differentiation of M1 cells. The inhibitory activity of TGF-beta 1 was 20 times
that of TGF-beta 2 on M1 cells. These results suggest that TGF-beta 1 inhibits
proliferation and dexamethasone-induced differentiation of M1 cells by
interacting with receptors that can distinguish between TGF-beta 1 and TGF-beta
2. TGF-beta 1 had a much lower inhibitory effect on the growth of a variant M1
cell clone, which was resistant to differentiation inducers, and it did not
induce adherence of the resistant M1 cells.