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10.1111/j.1349-7006.1989.tb02282.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1989.tb02282.x C5917695!5917695 !2498248     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=2498248 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors |pdf=|usr=}}{{2498248 }} gab.com Text Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2498248 #FOAvip T cells prepared from tumor (Meth A)-bearing mice were cocultured with homologous tumor cells and splenic dendritic cells to enrich tumor-specific T cells by the separation of clusters. T blasts generated from clusters were capable of inhibiting the in vivo tumor cell growth. The culture supernatant of clustering cells (CLSN) was effective in activating macrophages (M phi) to be cytostatic and cytocidal against tumor cells. Moreover, it was found that CLSN contains at least 3 distinct factors; one was identified as interferon-gamma (IFN-gamma), and the others are so far unidentified, but one acts synergistically with IFN-gamma, possibly as the second signal, and the other cooperates with lipopolysaccharide but not with IFN-gamma. We propose that the tumor-specific T cells secrete soluble mediators which cooperate with each other in M phi activation against tumor cells. Twit Text FOAVip Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=2498248 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2498248 #FOAvip English Wikipedia <ref>{{Cite pmid|2498248 }}</ref> Tumor-specific T cells which form clusters with dendritic cells and tumor cells and deliver macrophage-activating factors #MMPMID2498248 Yamaguchi Y ; Inaba K ; Kawai J ; Kato T ; Nakamura S ; Uno K ; Muramatsu S Jpn J Cancer Res 1989[Feb]; 80 (2 ): 141-9 PMID2498248 show ga T cells prepared from tumor (Meth A)-bearing mice were cocultured with homologous tumor cells and splenic dendritic cells to enrich tumor-specific T cells by the separation of clusters. T blasts generated from clusters were capable of inhibiting the in vivo tumor cell growth. The culture supernatant of clustering cells (CLSN) was effective in activating macrophages (M phi) to be cytostatic and cytocidal against tumor cells. Moreover, it was found that CLSN contains at least 3 distinct factors; one was identified as interferon-gamma (IFN-gamma), and the others are so far unidentified, but one acts synergistically with IFN-gamma, possibly as the second signal, and the other cooperates with lipopolysaccharide but not with IFN-gamma. We propose that the tumor-specific T cells secrete soluble mediators which cooperate with each other in M phi activation against tumor cells. |Animals [MESH] |Cell Adhesion [MESH] |Cytotoxicity, Immunologic [MESH] |Dendritic Cells/cytology/*immunology [MESH] |Female [MESH] |Interferon-gamma/immunology [MESH] |Lipopolysaccharides/immunology [MESH] |Lymphocyte Activation [MESH] |Lymphokines/*immunology [MESH] |Macrophage Activation [MESH] |Macrophage-Activating Factors [MESH] |Macrophages/immunology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C3H [MESH] |Mice, Nude [MESH] |T-Lymphocytes/cytology/*immunology [MESH]Tumor-specific T cells which form clusters with dendritic cells and tu(epmc).pdf DeepDyve Pubget Overpricing