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10.1111/j.1349-7006.1988.tb01563.x http://scihub22266oqcxt.onion/10.1111/j.1349-7006.1988.tb01563.x C5917657!5917657!3148603     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Jpn+J+Cancer+Res 1988 ; 79 (12): 1327-34 Nephropedia Template TP {{tp|p=3148603|t=1988. Involvement of the Kinin?generating Cascade in Enhanced Vascular Permeability in Tumor Tissue |pdf=|usr=}}{{3148603}} gab.com Text Involvement of the Kinin generating Cascade in Enhanced Vascular Permeability in Tumor Tissue JO: Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=3148603 #FOAvip Enhanced vascular permeability in tumor tissue has profound pathological consequences in tumor biology. However, details of the mechanism involved are not clear. The present work on tumor vascular permeability has led to the following three findings, (i) Ascitic tumor fluid contained kinin (about 1?40 ng/ml), which is known to enhance vascular permeability and induce pain in vivo, (ii) Kinin is generated via the kallikrein?dependent cascade in the ascitic tumor fluid. By blocking this kinin?generating cascade with Kunitz?type soybean trypsin inhibitor the formation of ascites was suppressed, (iii) Blocking of kinin?degrading enzymes (kininases I and II) by an appropriate kininase inhibitor (e.g., captopril) may result in increased permeability, leading to accumulation of the ascitic fluid. This phenomenon was verified by an about 1.2?1.5 fold increase in leakage of 51Cr?labeled bovine serum albumin into the ascites when kininase inhibitors had been administered orally 30 min before intravenous administration of the bovine serum albumin. Twit Text FOAVip Involvement of the Kinin generating Cascade in Enhanced Vascular Permeability in Tumor Tissue ????Jpn J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=3148603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=3148603 #FOAvip English Wikipedia <ref>{{Cite pmid|3148603}}</ref> Involvement of the Kinin?generating Cascade in Enhanced Vascular Permeability in Tumor Tissue #MMPMID3148603 Matsumura Y; Kimura M; Yamamoto T; Maeda H Jpn J Cancer Res 1988[Dec]; 79 (12): 1327-34 PMID3148603show ga Enhanced vascular permeability in tumor tissue has profound pathological consequences in tumor biology. However, details of the mechanism involved are not clear. The present work on tumor vascular permeability has led to the following three findings, (i) Ascitic tumor fluid contained kinin (about 1?40 ng/ml), which is known to enhance vascular permeability and induce pain in vivo, (ii) Kinin is generated via the kallikrein?dependent cascade in the ascitic tumor fluid. By blocking this kinin?generating cascade with Kunitz?type soybean trypsin inhibitor the formation of ascites was suppressed, (iii) Blocking of kinin?degrading enzymes (kininases I and II) by an appropriate kininase inhibitor (e.g., captopril) may result in increased permeability, leading to accumulation of the ascitic fluid. This phenomenon was verified by an about 1.2?1.5 fold increase in leakage of 51Cr?labeled bovine serum albumin into the ascites when kininase inhibitors had been administered orally 30 min before intravenous administration of the bovine serum albumin. äInvolvement of the Kinin?generating Cascade in Enhanced Vascular Perme(epmc).pdf DeepDyve Pubget Overpricing