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1988 ; 79
(2
): 236-43
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The dynamics of tumor cords in an irradiated mouse mammary carcinoma with a large
hypoxic cell component
#MMPMID3130358
Moore JV
Jpn J Cancer Res
1988[Feb]; 79
(2
): 236-43
PMID3130358
show ga
The tumor cord model represents a histologically based framework for
interpretation of radiobiological phenomena, particularly the resistance to
radiation conferred by absence of oxygen. For the mammary carcinoma T50/80 grown
in B6D2F1 male mice, average oxygenation was poor, based on tumor growth delay
after irradiation. There was no improvement in radiobiological oxygenation for
several days after a high dose of radiation. This was consistent with events in
the cords of the tumor, where although up to 20% of all cells became pyknotic by
8 hr, the cords did not shrink for at least 2 days. The cellular kinetics of
populations of intact and dead cells, adjacent to and remote from the capillaries
of the cords, were examined for up to 60 hr after irradiation and it was found
that: (i) before treatment, average LI (adjacent) was 13% and LI (remote) was 2%,
(ii) after irradiation, cells expressed pyknosis after passing through the S
phase of the cell cycle, so that (iii) at early intervals there was a larger
proportional rise in pyknotic cells in the adjacent than the remote zone.
However, (iv) at later intervals there was always a higher proportion of dead
cells in the remote zone.