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10.3389/fonc.2018.00117 http://scihub22266oqcxt.onion/10.3389/fonc.2018.00117 C5917075!5917075!29725585     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Oncol 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29725585|t=2018. Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming |pdf=|usr=}}{{29725585}} gab.com Text Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29725585 #FOAvip As with castles, tumor cells are fortified by surrounding non-malignant cells, such as cancer-associated fibroblasts, immune cells, but also nerve fibers and extracellular matrix. In most cancers, this fortification creates a considerable solid pressure which limits oxygen and nutrient delivery to the tumor cells and causes a hypoxic and nutritional stress. Consequently, tumor cells have to adapt their metabolism to survive and proliferate in this harsh microenvironment. To satisfy their need in energy and biomass, tumor cells develop new capacities to benefit from metabolites of the microenvironment, either by their uptake through the macropinocytosis process or through metabolite transporters, or by a cross-talk with stromal cells and capture of extracellular vesicles that are released by the neighboring cells. However, the microenvironments of primary tumor and metastatic niches differ tremendously in their cellular/acellular components and available nutrients. Therefore, cancer cells must develop a metabolic flexibility conferring on them the ability to satisfy their biomass and energetic demands at both primary and metastasis sites. In this review, we propose a brief overview of how proliferating cancer cells take advantage of their surrounding microenvironment to satisfy their high metabolic demand at both primary and metastasis sites. Twit Text FOAVip Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29725585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29725585 #FOAvip English Wikipedia <ref>{{Cite pmid|29725585}}</ref> Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming #MMPMID29725585 Gouirand V; Guillaumond F; Vasseur S Front Oncol 2018[]; 8 (ä): ä PMID29725585show ga As with castles, tumor cells are fortified by surrounding non-malignant cells, such as cancer-associated fibroblasts, immune cells, but also nerve fibers and extracellular matrix. In most cancers, this fortification creates a considerable solid pressure which limits oxygen and nutrient delivery to the tumor cells and causes a hypoxic and nutritional stress. Consequently, tumor cells have to adapt their metabolism to survive and proliferate in this harsh microenvironment. To satisfy their need in energy and biomass, tumor cells develop new capacities to benefit from metabolites of the microenvironment, either by their uptake through the macropinocytosis process or through metabolite transporters, or by a cross-talk with stromal cells and capture of extracellular vesicles that are released by the neighboring cells. However, the microenvironments of primary tumor and metastatic niches differ tremendously in their cellular/acellular components and available nutrients. Therefore, cancer cells must develop a metabolic flexibility conferring on them the ability to satisfy their biomass and energetic demands at both primary and metastasis sites. In this review, we propose a brief overview of how proliferating cancer cells take advantage of their surrounding microenvironment to satisfy their high metabolic demand at both primary and metastasis sites. äInfluence of the Tumor Microenvironment on Cancer Cells Metabolic Repr(epmc).pdf DeepDyve Pubget Overpricing