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10.1097/MD.0000000000010343 http://scihub22266oqcxt.onion/10.1097/MD.0000000000010343 C5916697!5916697 !29668584     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29668584 &cmd=llinks): Failed to open stream: HTTP request failed! 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Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study |pdf=|usr=}}{{29668584 }} gab.com Text Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=29668584 #FOAvip The aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (uMCP-1) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (uTWEAK) could serve as a screening test for proteinuria in patients with lupus nephritis (LN).A case-control study that contained 39 biopsy-proven LN patients, 20 non-LN systemic lupus erythematosus (SLE) patients, and 10 healthy controls (HCs) were carried out. Correlations between uMCP-1, uTWEAK, and traditional clinical markers were analyzed by Spearman correlation test. Diagnostic values of uMCP-1, uTWEAK, and urine albumin/creatinine ratio (uACR) in the assessment of proteinuria were investigated by receiver operating characteristic (ROC) curves.Biopsy-proven LN patients showed higher levels of uMCP-1 and uTWEAK than non-LN patients. uMCP-1 and uTWEAK were elevated in renal active patients (rSLEDAI ?4). Both uMCP-1 and uTWEAK showed significant correlation with patients' rSLEDAI, 24-hour urine proteinuria (24hr UP), and anti-double-stranded DNA (anti-dsDNA) antibodies. No correlations of these 2 biomarkers between cystatin C (Cys-C), creatinine (Cr), and blood urea nitrogen (BUN) were observed. An algorithm combining the moderate sensitivity of uMCP-1 and high specificity of uTWEAK displayed great specificity and sensitivity for proteinuria screening.Both uMCP-1 and uTWEAK were positively correlated with the impairments of LN, and the combined utility of untimed single uMCP-1 and uTWEAK might be used as potential predictors for proteinuria in LN. Twit Text FOAVip Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=29668584 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29668584 #FOAvip English Wikipedia <ref>{{Cite pmid|29668584 }}</ref> Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study #MMPMID29668584 Dong X ; Zheng Z ; Luo X ; Ding J ; Li Y ; Li Z ; Li S ; Rong M ; Fu Y ; Wu Z ; Zhu P Medicine (Baltimore) 2018[Apr]; 97 (16 ): e0343 PMID29668584 show ga The aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (uMCP-1) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (uTWEAK) could serve as a screening test for proteinuria in patients with lupus nephritis (LN).A case-control study that contained 39 biopsy-proven LN patients, 20 non-LN systemic lupus erythematosus (SLE) patients, and 10 healthy controls (HCs) were carried out. Correlations between uMCP-1, uTWEAK, and traditional clinical markers were analyzed by Spearman correlation test. Diagnostic values of uMCP-1, uTWEAK, and urine albumin/creatinine ratio (uACR) in the assessment of proteinuria were investigated by receiver operating characteristic (ROC) curves.Biopsy-proven LN patients showed higher levels of uMCP-1 and uTWEAK than non-LN patients. uMCP-1 and uTWEAK were elevated in renal active patients (rSLEDAI ?4). Both uMCP-1 and uTWEAK showed significant correlation with patients' rSLEDAI, 24-hour urine proteinuria (24hr UP), and anti-double-stranded DNA (anti-dsDNA) antibodies. No correlations of these 2 biomarkers between cystatin C (Cys-C), creatinine (Cr), and blood urea nitrogen (BUN) were observed. An algorithm combining the moderate sensitivity of uMCP-1 and high specificity of uTWEAK displayed great specificity and sensitivity for proteinuria screening.Both uMCP-1 and uTWEAK were positively correlated with the impairments of LN, and the combined utility of untimed single uMCP-1 and uTWEAK might be used as potential predictors for proteinuria in LN. |*Lupus Nephritis/complications/diagnosis [MESH] |*Proteinuria/diagnosis/etiology [MESH] |*Urinalysis/methods/statistics & numerical data [MESH] |Adult [MESH] |Biomarkers/urine [MESH] |Biopsy/methods [MESH] |Chemokine CCL2/*urine [MESH] |Creatinine/analysis [MESH] |Cytokine TWEAK/*urine [MESH] |Female [MESH] |Humans [MESH] |Kidney/pathology [MESH] |Male [MESH] |Mass Screening/methods/statistics & numerical data [MESH] |Predictive Value of Tests [MESH] |ROC Curve [MESH] |Sensitivity and Specificity [MESH]Combined utilization of untimed single urine of MCP-1 and TWEAK as a p(epmc).pdf DeepDyve Pubget Overpricing