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10.1038/s41598-018-24712-5 http://scihub22266oqcxt.onion/10.1038/s41598-018-24712-5 C5915420!5915420 !29691438     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29691438 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis |pdf=|usr=}}{{29691438 }} gab.com Text The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29691438 #FOAvip Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal. TAZ (transcriptional coactivator with the PDZ-binding motif) is a key downstream effector of the mammalian Hippo pathway. Here, using a transgenic mouse model with mammary-gland-specific expression of constitutively active TAZ, we found that TAZ induction in mammary epithelial cells was associated with an increase in mammary glandular size, which probably resulted from adipocyte hypertrophy. Consistent with its known oncogenic potential, we observed tumor formation in TAZ transgenic mice after administration of the carcinogen 7,12-dimethylbenzanthracene (DMBA) and demonstrated that tumorigenesis was reliant on the presence of TAZ. Our findings establish a previously unknown roles of TAZ in regulating both mammary gland morphogenesis as well as carcinogen-induced mammary tumor formation. Twit Text FOAVip The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29691438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29691438 #FOAvip English Wikipedia <ref>{{Cite pmid|29691438 }}</ref> The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis #MMPMID29691438 Denson KE ; Mussell AL ; Shen H ; Truskinovsky A ; Yang N ; Parashurama N ; Chen Y ; Frangou C ; Yang F ; Zhang J Sci Rep 2018[Apr]; 8 (1 ): 6449 PMID29691438 show ga Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal. TAZ (transcriptional coactivator with the PDZ-binding motif) is a key downstream effector of the mammalian Hippo pathway. Here, using a transgenic mouse model with mammary-gland-specific expression of constitutively active TAZ, we found that TAZ induction in mammary epithelial cells was associated with an increase in mammary glandular size, which probably resulted from adipocyte hypertrophy. Consistent with its known oncogenic potential, we observed tumor formation in TAZ transgenic mice after administration of the carcinogen 7,12-dimethylbenzanthracene (DMBA) and demonstrated that tumorigenesis was reliant on the presence of TAZ. Our findings establish a previously unknown roles of TAZ in regulating both mammary gland morphogenesis as well as carcinogen-induced mammary tumor formation. |Adaptor Proteins, Signal Transducing/metabolism/physiology [MESH] |Animals [MESH] |Apoptosis [MESH] |Carcinogenesis/metabolism [MESH] |Cell Proliferation [MESH] |Cell Transformation, Neoplastic [MESH] |Epithelial Cells/metabolism [MESH] |Female [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*metabolism/*physiology [MESH] |Mammary Glands, Animal/*metabolism [MESH] |Mammary Neoplasms, Animal/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Protein Serine-Threonine Kinases/metabolism/physiology [MESH] |Signal Transduction [MESH] |Trans-Activators [MESH] |Transcription Factors/metabolism [MESH]The Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenes(epmc).pdf DeepDyve Pubget Overpricing