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10.1289/EHP1302

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suck abstract from ncbi


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pmid28953452
      Environ+Health+Perspect 2017 ; 125 (9 ): 097020
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  • Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed #MMPMID28953452
  • Jacobson MH ; Darrow LA ; Barr DB ; Howards PP ; Lyles RH ; Terrell ML ; Smith AK ; Conneely KN ; Marder ME ; Marcus M
  • Environ Health Perspect 2017[Sep]; 125 (9 ): 097020 PMID28953452 show ga
  • BACKGROUND: In 1973-1974, Michigan residents were exposed to polybrominated biphenyls (PBBs) through an accidental contamination of the food supply. Residents were enrolled in a registry assembled after the incident, and they and their children participated in follow-up studies to assess subsequent health outcomes. OBJECTIVES: We evaluated associations between serum PBBs and polychlorinated biphenyls (PCBs) and markers of thyroid function among Michigan adults. METHODS: Serum concentrations of four PBB and four PCB congeners were measured at least once in 753 adults, including 79 women who participated in a 2004-2006 study and 683 women and men with follow-up during 2012-2015. Participants completed questionnaires on health conditions (including physician-diagnosed thyroid disease), behaviors, and demographics. Thyroid hormones were measured in a subset without thyroid disease (n=551). In multivariable linear regression models, PBB and PCB congener concentrations, on both the volume (nanogram/milliliter) and lipid (nanogram/gram lipid) basis, were assessed in relation to thyroid hormones. Logistic regression models were used to estimate associations between serum PBBs and PCBs and thyroid disease. RESULTS: Thyroid disease was common (18% overall; 25% among women). Among women, all odds ratios (ORs) for PBB-153 and thyroid disease were positive for quintiles above the reference level, but estimates were imprecise and were without a monotonic increase. For an interquartile range (IQR) increase in PBB-153 (0.43?ng/mL), the OR?(any?thyroid?disease)=1.12; (95% CI: 0.83, 1.52) (n=105?cases); for hypothyroidism, OR=1.35 (95% CI: 0.86, 2.13) (n=49?cases). There were 21 cases of thyroid disease in men [OR=0.69 (95% CI: 0.33); 1.44 for an IQR increase (0.75?ng/mL) in serum PBB-153]. PCB congeners were statistically significantly associated with greater total and free thyroxine and total triiodothyronine among women and with total and free triiodothyronine among men in lipid-standardized models. CONCLUSIONS: We found some evidence to support associations of PBBs and PCBs with thyroid disease and thyroid hormone levels. https://doi.org/10.1289/EHP1302.
  • |Adult [MESH]
  • |Animal Feed/*analysis [MESH]
  • |Environmental Exposure/analysis/*statistics & numerical data [MESH]
  • |Environmental Pollutants/*blood [MESH]
  • |Female [MESH]
  • |Food Contamination/*analysis [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Michigan [MESH]
  • |Polybrominated Biphenyls/*blood [MESH]
  • |Polychlorinated Biphenyls/*blood [MESH]


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