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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Environ+Health+Perspect
2017 ; 125
(9
): 097020
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and
Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB
Contamination of Livestock Feed
#MMPMID28953452
Jacobson MH
; Darrow LA
; Barr DB
; Howards PP
; Lyles RH
; Terrell ML
; Smith AK
; Conneely KN
; Marder ME
; Marcus M
Environ Health Perspect
2017[Sep]; 125
(9
): 097020
PMID28953452
show ga
BACKGROUND: In 1973-1974, Michigan residents were exposed to polybrominated
biphenyls (PBBs) through an accidental contamination of the food supply.
Residents were enrolled in a registry assembled after the incident, and they and
their children participated in follow-up studies to assess subsequent health
outcomes. OBJECTIVES: We evaluated associations between serum PBBs and
polychlorinated biphenyls (PCBs) and markers of thyroid function among Michigan
adults. METHODS: Serum concentrations of four PBB and four PCB congeners were
measured at least once in 753 adults, including 79 women who participated in a
2004-2006 study and 683 women and men with follow-up during 2012-2015.
Participants completed questionnaires on health conditions (including
physician-diagnosed thyroid disease), behaviors, and demographics. Thyroid
hormones were measured in a subset without thyroid disease (n=551). In
multivariable linear regression models, PBB and PCB congener concentrations, on
both the volume (nanogram/milliliter) and lipid (nanogram/gram lipid) basis, were
assessed in relation to thyroid hormones. Logistic regression models were used to
estimate associations between serum PBBs and PCBs and thyroid disease. RESULTS:
Thyroid disease was common (18% overall; 25% among women). Among women, all odds
ratios (ORs) for PBB-153 and thyroid disease were positive for quintiles above
the reference level, but estimates were imprecise and were without a monotonic
increase. For an interquartile range (IQR) increase in PBB-153 (0.43?ng/mL), the
OR?(any?thyroid?disease)=1.12; (95% CI: 0.83, 1.52) (n=105?cases); for
hypothyroidism, OR=1.35 (95% CI: 0.86, 2.13) (n=49?cases). There were 21 cases of
thyroid disease in men [OR=0.69 (95% CI: 0.33); 1.44 for an IQR increase
(0.75?ng/mL) in serum PBB-153]. PCB congeners were statistically significantly
associated with greater total and free thyroxine and total triiodothyronine among
women and with total and free triiodothyronine among men in lipid-standardized
models. CONCLUSIONS: We found some evidence to support associations of PBBs and
PCBs with thyroid disease and thyroid hormone levels.
https://doi.org/10.1289/EHP1302.
|Adult
[MESH]
|Animal Feed/*analysis
[MESH]
|Environmental Exposure/analysis/*statistics & numerical data
[MESH]