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10.18632/oncotarget.24649 http://scihub22266oqcxt.onion/10.18632/oncotarget.24649 C5915053!5915053!29719586     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (26): 18002-17 Nephropedia Template TP {{tp|p=29719586|t=2018. Cold atmospheric plasma as a potential tool for multiple myeloma treatment |pdf=|usr=}}{{29719586}} gab.com Text Cold atmospheric plasma as a potential tool for multiple myeloma treatment JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29719586 #FOAvip Multiple myeloma (MM) is a fatal and incurable hematological malignancy thus new therapy need to be developed. Cold atmospheric plasma, a new technology that could generate various active species, could efficiently induce various tumor cells apoptosis. More details about the interaction of plasma and tumor cells need to be addressed before the application of gas plasma in clinical cancer treatment. In this study, we demonstrate that He+O2 plasma could efficiently induce myeloma cell apoptosis through the activation of CD95 and downstream caspase cascades. Extracellular and intracellular reactive oxygen species (ROS) accumulation is essential for CD95-mediated cell apoptosis in response to plasma treatment. Furthermore, p53 is shown to be a key transcription factor in activating CD95 and caspase cascades. More importantly, we demonstrate that CD95 expression is higher in tumor cells than in normal cells in both MM cell lines and MM clinical samples, which suggests that CD95 could be a favorable target for plasma treatment as it could selectively inactivate myeloma tumor cells. Our results illustrate the molecular details of plasma induced myeloma cell apoptosis and it shows that gas plasma could be a potential tool for myeloma therapy in the future. Twit Text FOAVip Cold atmospheric plasma as a potential tool for multiple myeloma treatment ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29719586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29719586 #FOAvip English Wikipedia <ref>{{Cite pmid|29719586}}</ref> Cold atmospheric plasma as a potential tool for multiple myeloma treatment #MMPMID29719586 Xu D; Xu Y; Cui Q; Liu D; Liu Z; Wang X; Yang Y; Feng M; Liang R; Chen H; Ye K; Kong MG Oncotarget 2018[Apr]; 9 (26): 18002-17 PMID29719586show ga Multiple myeloma (MM) is a fatal and incurable hematological malignancy thus new therapy need to be developed. Cold atmospheric plasma, a new technology that could generate various active species, could efficiently induce various tumor cells apoptosis. More details about the interaction of plasma and tumor cells need to be addressed before the application of gas plasma in clinical cancer treatment. In this study, we demonstrate that He+O2 plasma could efficiently induce myeloma cell apoptosis through the activation of CD95 and downstream caspase cascades. Extracellular and intracellular reactive oxygen species (ROS) accumulation is essential for CD95-mediated cell apoptosis in response to plasma treatment. Furthermore, p53 is shown to be a key transcription factor in activating CD95 and caspase cascades. More importantly, we demonstrate that CD95 expression is higher in tumor cells than in normal cells in both MM cell lines and MM clinical samples, which suggests that CD95 could be a favorable target for plasma treatment as it could selectively inactivate myeloma tumor cells. Our results illustrate the molecular details of plasma induced myeloma cell apoptosis and it shows that gas plasma could be a potential tool for myeloma therapy in the future. äCold atmospheric plasma as a potential tool for multiple myeloma treat(epmc).pdf DeepDyve Pubget Overpricing