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10.3389/fphar.2018.00341

http://scihub22266oqcxt.onion/10.3389/fphar.2018.00341
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C5914301!5914301!29719508
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suck abstract from ncbi


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pmid29719508      Front+Pharmacol 2018 ; 9 (ä): ä
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  • The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions #MMPMID29719508
  • Janciauskiene S; Wrenger S; Immenschuh S; Olejnicka B; Greulich T; Welte T; Chorostowska-Wynimko J
  • Front Pharmacol 2018[]; 9 (ä): ä PMID29719508show ga
  • Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.
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