Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29732060
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29732060
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Chem+Sci
2018 ; 9
(10
): 2756-2761
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Multicolor monitoring of cellular organelles by single wavelength excitation to
visualize the mitophagy process
#MMPMID29732060
Hu F
; Cai X
; Manghnani PN
; Kenry
; Wu W
; Liu B
Chem Sci
2018[Mar]; 9
(10
): 2756-2761
PMID29732060
show ga
Multiplexed cellular organelle imaging using single wavelength excitation is
highly desirable for unravelling cellular functions but remains challenging. This
requires the design of organelle specific fluorophores with distinct emission but
similar absorption. Herein, we present two unique aggregation-induced emission
(AIE) probes to track mitochondria and lysosomes simultaneously with emission
colors that can be distinguished from that of the nucleus stain Hoechst 33342
upon single wavelength excitation. Compared to conventional organelle stains, the
two AIE probes have larger Stokes shifts and higher photostability, which endow
them with the capability to monitor bioprocesses, such as mitophagy with strong
and sustained fluorescent signals. Moreover, both probes can also stain
intracellular organelles in zebrafish larvae with good cell-penetrating
capabilities, showing their great potential to monitor bioprocesses in vivo.