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10.1155/2018/5246976

http://scihub22266oqcxt.onion/10.1155/2018/5246976
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C5914097!5914097!29850606
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suck abstract from ncbi


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pmid29850606      J+Diabetes+Res 2018 ; 2018 (ä): ä
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  • Dipeptidyl Peptidase-4 Inhibitors and the Risk of Pancreatitis in Patients with Type 2 Diabetes Mellitus: A Population-Based Cohort Study #MMPMID29850606
  • Kim YG; Kim S; Han SJ; Kim DJ; Lee KW; Kim HJ
  • J Diabetes Res 2018[]; 2018 (ä): ä PMID29850606show ga
  • Background: Information on the risk of acute pancreatitis in patients receiving dipeptidyl-peptidase IV inhibitors (DPP-4i) is limited and controversial. One study suggested that the differences in findings between these meta-analyses were attributed to whether they included large randomized control trials with cardiovascular outcomes or not. The aim of our study was to determine whether the use of DPP-4i increases the risk of acute pancreatitis compared with sulfonylurea (SU) and whether the risk is higher in patients with underlying cardiovascular disease (CVD). Methods: A population-based cohort study was performed using Korean National Health Insurance Service-National Sample Cohort data. We included 33,395 new users of SU and DPP-4i from 1 January 2008 to 31 December 2015. SU-treated patients and DPP-4i-treated patients were matched by 1?:?1 propensity score matching. We used Kaplan?Meier curves and Cox proportional hazards regression analysis to calculate the risk of acute pancreatitis. Results: The hazard ratio (HR) of hospitalization for acute pancreatitis was 0.642 (95% confidence interval (CI): 0.535?0.771) in DPP-4i-treated patients compared with SU-treated patients. The HR of DPP-4i use was also lower than that of SU use in patients without underlying CVD (HR: 0.591; 95% CI: 0.476?0.735) but not in patients with underlying CVD (HR: 0.727; 95% CI: 0.527?1.003). Conclusion: Our findings suggest that DPP-4i is less likely to cause drug-induced pancreatitis than SU. This finding was not evident in patients with CVD, but DPP-4i was not more likely to induce pancreatitis in these patients than SU was.
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