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10.1186/s12929-018-0440-6

http://scihub22266oqcxt.onion/10.1186/s12929-018-0440-6
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C5913878!5913878!29685144
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suck abstract from ncbi


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pmid29685144      J+Biomed+Sci 2018 ; 25 (ä): ä
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  • Emerging roles of epithelial-mesenchymal transition in hematological malignancies #MMPMID29685144
  • Chen SC; Liao TT; Yang MH
  • J Biomed Sci 2018[]; 25 (ä): ä PMID29685144show ga
  • Background: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions: Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.
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