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10.3389/fimmu.2018.00779 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00779 C5913575!5913575!29719538     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29719538|t=2018. Humoral Epitope Spreading in Autoimmune Bullous Diseases |pdf=|usr=}}{{29719538}} gab.com Text Humoral Epitope Spreading in Autoimmune Bullous Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29719538 #FOAvip Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response. All these findings could give useful information to better understand autoimmune disease pathogenesis and to design antigen/epitope specific therapeutic approaches. Twit Text FOAVip Humoral Epitope Spreading in Autoimmune Bullous Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29719538 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29719538 #FOAvip English Wikipedia <ref>{{Cite pmid|29719538}}</ref> Humoral Epitope Spreading in Autoimmune Bullous Diseases #MMPMID29719538 Didona D; Di Zenzo G Front Immunol 2018[]; 9 (ä): ä PMID29719538show ga Autoimmune blistering diseases are characterized by autoantibodies against structural adhesion proteins of the skin and mucous membranes. Extensive characterization of their autoantibody targets has improved understanding of pathogenesis and laid the basis for the study of antigens/epitopes diversification, a process termed epitope spreading (ES). In this review, we have reported and discussed ES phenomena in autoimmune bullous diseases and underlined their functional role in disease pathogenesis. A functional ES has been proposed: (1) in bullous pemphigoid patients and correlates with the initial phase of the disease, (2) in pemphigus vulgaris patients with mucosal involvement during the clinical transition to a mucocutaneous form, (3) in endemic pemphigus foliaceus, underlining its role in disease pathogenesis, and (4) in numerous cases of disease transition associated with an intermolecular diversification of immune response. All these findings could give useful information to better understand autoimmune disease pathogenesis and to design antigen/epitope specific therapeutic approaches. äHumoral Epitope Spreading in Autoimmune Bullous Diseases (epmc).pdf DeepDyve Pubget Overpricing