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10.3389/fnins.2018.00249 http://scihub22266oqcxt.onion/10.3389/fnins.2018.00249 C5913346!5913346!29719499     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Neurosci 2018 ; 12 (ä): ä Nephropedia Template TP {{tp|p=29719499|t=2018. Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders |pdf=|usr=}}{{29719499}} gab.com Text Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders JO: Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29719499 #FOAvip Neurodegenerative diseases represent a class of fatal brain disorders for which the number of effective therapeutic options remains limited with only symptomatic treatment accessible. Multiple studies show that defects in sphingolipid pathways are shared among different brain disorders including neurodegenerative diseases and may contribute to their complex pathogenesis. In this mini review, we discuss the hypothesis that modulation of sphingolipid metabolism and their related signaling pathways may represent a potential therapeutic approach for those devastating conditions. The plausible ?druggability? of sphingolipid pathways is greatly promising and represent a relevant feature that brings real advantage to the development of new therapeutic options for these conditions. Indeed, several molecules that selectively target sphingolipds are already available and many of them currently in clinical trial for human diseases. A deeper understanding of the ?sphingolipid scenario? in neurodegenerative disorders would certainly enhance therapeutic perspectives for these conditions, by taking advantage from the already available molecules and by promoting the development of new ones. Twit Text FOAVip Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders ????Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=29719499 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29719499 #FOAvip English Wikipedia <ref>{{Cite pmid|29719499}}</ref> Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders #MMPMID29719499 Di Pardo A; Maglione V Front Neurosci 2018[]; 12 (ä): ä PMID29719499show ga Neurodegenerative diseases represent a class of fatal brain disorders for which the number of effective therapeutic options remains limited with only symptomatic treatment accessible. Multiple studies show that defects in sphingolipid pathways are shared among different brain disorders including neurodegenerative diseases and may contribute to their complex pathogenesis. In this mini review, we discuss the hypothesis that modulation of sphingolipid metabolism and their related signaling pathways may represent a potential therapeutic approach for those devastating conditions. The plausible ?druggability? of sphingolipid pathways is greatly promising and represent a relevant feature that brings real advantage to the development of new therapeutic options for these conditions. Indeed, several molecules that selectively target sphingolipds are already available and many of them currently in clinical trial for human diseases. A deeper understanding of the ?sphingolipid scenario? in neurodegenerative disorders would certainly enhance therapeutic perspectives for these conditions, by taking advantage from the already available molecules and by promoting the development of new ones. äSphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degen(epmc).pdf DeepDyve Pubget Overpricing