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10.1038/s41467-018-03886-6 http://scihub22266oqcxt.onion/10.1038/s41467-018-03886-6 C5913134!5913134 !29686383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29686383 &cmd=llinks): Failed to open stream: HTTP request failed! 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The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation |pdf=|usr=}}{{29686383 }} gab.com Text The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29686383 #FOAvip Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines mRNAs, but the function of PIN1 in upstream signaling pathways in asthma is unknown. Here we show that interleukin receptor associated kinase M (IRAK-M) is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. Upon IL-33-induced airway inflammation, PIN1 is activated for binding with and isomerization of IRAK-M, resulting in IRAK-M nuclear translocation and induction of selected proinflammatory genes in dendritic cells. Thus, the IL-33-PIN1-IRAK-M is an axis critical for dendritic cell activation, type 2 immunity and IL-33 induced airway inflammation. Twit Text FOAVip The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29686383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29686383 #FOAvip English Wikipedia <ref>{{Cite pmid|29686383 }}</ref> The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation #MMPMID29686383 Nechama M ; Kwon J ; Wei S ; Kyi AT ; Welner RS ; Ben-Dov IZ ; Arredouani MS ; Asara JM ; Chen CH ; Tsai CY ; Nelson KF ; Kobayashi KS ; Israel E ; Zhou XZ ; Nicholson LK ; Lu KP Nat Commun 2018[Apr]; 9 (1 ): 1603 PMID29686383 show ga Interleukin 33 (IL-33) is among the earliest-released cytokines in response to allergens that orchestrate type 2 immunity. The prolyl cis-trans isomerase PIN1 is known to induce cytokines for eosinophil survival and activation by stabilizing cytokines mRNAs, but the function of PIN1 in upstream signaling pathways in asthma is unknown. Here we show that interleukin receptor associated kinase M (IRAK-M) is a PIN1 target critical for IL-33 signaling in allergic asthma. NMR analysis and docking simulations suggest that PIN1 might regulate IRAK-M conformation and function in IL-33 signaling. Upon IL-33-induced airway inflammation, PIN1 is activated for binding with and isomerization of IRAK-M, resulting in IRAK-M nuclear translocation and induction of selected proinflammatory genes in dendritic cells. Thus, the IL-33-PIN1-IRAK-M is an axis critical for dendritic cell activation, type 2 immunity and IL-33 induced airway inflammation. |*Immunity, Cellular [MESH] |Adult [MESH] |Animals [MESH] |Antigens, Dermatophagoides/immunology [MESH] |Asthma/blood/*immunology/pathology [MESH] |Bronchial Provocation Tests [MESH] |Bronchoalveolar Lavage Fluid/cytology [MESH] |Cell Line [MESH] |Disease Models, Animal [MESH] |Eosinophils/immunology [MESH] |Female [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Interleukin-1 Receptor-Associated Kinases/chemistry/genetics/*metabolism [MESH] |Interleukin-33/*immunology/metabolism [MESH] |Lung/immunology/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Molecular Docking Simulation [MESH] |NIMA-Interacting Peptidylprolyl Isomerase/chemistry/genetics/*metabolism [MESH] |Primary Cell Culture [MESH] |Protein Domains [MESH] |Signal Transduction/immunology [MESH] |Th2 Cells/*immunology/metabolism [MESH]The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-in(epmc).pdf DeepDyve Pubget Overpricing