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10.1016/j.celrep.2018.03.070 http://scihub22266oqcxt.onion/10.1016/j.celrep.2018.03.070 C5912948!5912948 !29641994     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29641994 &cmd=llinks): Failed to open stream: HTTP request failed! 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A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure |pdf=|usr=}}{{29641994 }} gab.com Text A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29641994 #FOAvip Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and beneficial effects of targeting FGF21. We replicated the association between the A allele and higher percentage carbohydrate intake. We then showed that this allele is more strongly associated with higher blood pressure and waist-hip ratio, despite an association with lower total body-fat percentage, than it is with BMI or type 2 diabetes. These human phenotypes of variation in the FGF21 gene will inform research into FGF21's mechanisms and therapeutic potential. Twit Text FOAVip A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=29641994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29641994 #FOAvip English Wikipedia <ref>{{Cite pmid|29641994 }}</ref> A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure #MMPMID29641994 Frayling TM ; Beaumont RN ; Jones SE ; Yaghootkar H ; Tuke MA ; Ruth KS ; Casanova F ; West B ; Locke J ; Sharp S ; Ji Y ; Thompson W ; Harrison J ; Etheridge AS ; Gallins PJ ; Jima D ; Wright F ; Zhou Y ; Innocenti F ; Lindgren CM ; Grarup N ; Murray A ; Freathy RM ; Weedon MN ; Tyrrell J ; Wood AR Cell Rep 2018[Apr]; 23 (2 ): 327-336 PMID29641994 show ga Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and beneficial effects of targeting FGF21. We replicated the association between the A allele and higher percentage carbohydrate intake. We then showed that this allele is more strongly associated with higher blood pressure and waist-hip ratio, despite an association with lower total body-fat percentage, than it is with BMI or type 2 diabetes. These human phenotypes of variation in the FGF21 gene will inform research into FGF21's mechanisms and therapeutic potential. |*Blood Pressure [MESH] |*Body Fat Distribution [MESH] |Adult [MESH] |Aged [MESH] |Alcohol Drinking [MESH] |Alleles [MESH] |Body Mass Index [MESH] |Body Size [MESH] |Databases, Factual [MESH] |Diabetes Mellitus, Type 2/genetics/pathology [MESH] |Diet, High-Fat [MESH] |Fibroblast Growth Factors/*genetics [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH] |Middle Aged [MESH] |Phenotype [MESH] |Polymorphism, Single Nucleotide [MESH] |Sugars/*metabolism [MESH]A Common Allele in FGF21 Associated with Sugar Intake Is Associated wi(epmc).pdf DeepDyve Pubget Overpricing