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10.1038/s41570-018-0115 http://scihub22266oqcxt.onion/10.1038/s41570-018-0115 C5912323!5912323!29696152     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Chem 2018 ; 2 (2): ä Nephropedia Template TP {{tp|p=29696152|t=2018. Toward Generalization of Iterative Small Molecule Synthesis |pdf=|usr=}}{{29696152}} gab.com Text Toward Generalization of Iterative Small Molecule Synthesis JO: Nat Rev Chem http://www.kidney.de/pget.php?&tw=1&pmid=29696152 #FOAvip Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the customized approach currently used to synthesize this class of chemical matter. In contrast, the ?building block approach?, i.e., generalized iterative assembly of interchangeable parts, has now proven to be a highly efficient and flexible way to construct things ranging all the way from skyscrapers to macromolecules to artificial intelligence algorithms. The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that improve access to specific classes of small molecules. There has also been substantial recent progress toward the iterative assembly of many different types of small molecules, including complex natural products, pharmaceuticals, biological probes, and materials, using common building blocks and coupling chemistry. Collectively, these advances suggest that a generalized building block approach for small molecule synthesis may be within reach. Twit Text FOAVip Toward Generalization of Iterative Small Molecule Synthesis ????Nat Rev Chem http://www.kidney.de/pget.php?&tw=1&pmid=29696152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29696152 #FOAvip English Wikipedia <ref>{{Cite pmid|29696152}}</ref> Toward Generalization of Iterative Small Molecule Synthesis #MMPMID29696152 Lehmann JW; Blair DJ; Burke MD Nat Rev Chem 2018[Feb]; 2 (2): ä PMID29696152show ga Small molecules have extensive untapped potential to benefit society, but access to this potential is too often restricted by limitations inherent to the customized approach currently used to synthesize this class of chemical matter. In contrast, the ?building block approach?, i.e., generalized iterative assembly of interchangeable parts, has now proven to be a highly efficient and flexible way to construct things ranging all the way from skyscrapers to macromolecules to artificial intelligence algorithms. The structural redundancy found in many small molecules suggests that they possess a similar capacity for generalized building block-based construction. It is also encouraging that many customized iterative synthesis methods have been developed that improve access to specific classes of small molecules. There has also been substantial recent progress toward the iterative assembly of many different types of small molecules, including complex natural products, pharmaceuticals, biological probes, and materials, using common building blocks and coupling chemistry. Collectively, these advances suggest that a generalized building block approach for small molecule synthesis may be within reach. äToward Generalization of Iterative Small Molecule Synthesis (epmc).pdf DeepDyve Pubget Overpricing