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10.1073/pnas.1802811115 http://scihub22266oqcxt.onion/10.1073/pnas.1802811115 C5910873!5910873!29581305     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (16): 4206-11 Nephropedia Template TP {{tp|p=29581305|t=2018. Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts |pdf=|usr=}}{{29581305}} gab.com Text Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29581305 #FOAvip The lamin proteins are an important component of the nuclear scaffold. Abnormal lamins can cause a variety of disorders called laminopathies, one of which is the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Cells from HGPS patients show improvement when treated with rapamycin and everolimus. These drugs stimulate the cellular system that disposes of abnormal proteins. Several other laminopathies also produce abnormal lamin proteins, so we hypothesized that everolimus would also be beneficial. We treated cells from six different laminopathy patients with everolimus and saw improved nuclear shape in most cells. Treatment also increased the cells? ability to multiply and delayed senescence. These results suggest that everolimus might have clinical benefit for multiple laminopathy syndromes. Twit Text FOAVip Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29581305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29581305 #FOAvip English Wikipedia <ref>{{Cite pmid|29581305}}</ref> Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts #MMPMID29581305 DuBose AJ; Lichtenstein ST; Petrash NM; Erdos MR; Gordon LB; Collins FS Proc Natl Acad Sci U S A 2018[Apr]; 115 (16): 4206-11 PMID29581305show ga The lamin proteins are an important component of the nuclear scaffold. Abnormal lamins can cause a variety of disorders called laminopathies, one of which is the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Cells from HGPS patients show improvement when treated with rapamycin and everolimus. These drugs stimulate the cellular system that disposes of abnormal proteins. Several other laminopathies also produce abnormal lamin proteins, so we hypothesized that everolimus would also be beneficial. We treated cells from six different laminopathy patients with everolimus and saw improved nuclear shape in most cells. Treatment also increased the cells? ability to multiply and delayed senescence. These results suggest that everolimus might have clinical benefit for multiple laminopathy syndromes. äEverolimus rescues multiple cellular defects in laminopathy-patient fi(epmc).pdf DeepDyve Pubget Overpricing