Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1715277115 http://scihub22266oqcxt.onion/10.1073/pnas.1715277115 C5910818!5910818 !29610298     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29610298 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29610298 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (16 ): E3682-E3691 Nephropedia Template TP {{tp|p=29610298 |t=2018. Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis |pdf=|usr=}}{{29610298 }} gab.com Text Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29610298 #FOAvip Hemodynamic forces and Notch signaling are both known as key regulators of arterial remodeling and homeostasis. However, how these two factors integrate in vascular morphogenesis and homeostasis is unclear. Here, we combined experiments and modeling to evaluate the impact of the integration of mechanics and Notch signaling on vascular homeostasis. Vascular smooth muscle cells (VSMCs) were cyclically stretched on flexible membranes, as quantified via video tracking, demonstrating that the expression of Jagged1, Notch3, and target genes was down-regulated with strain. The data were incorporated in a computational framework of Notch signaling in the vascular wall, where the mechanical load was defined by the vascular geometry and blood pressure. Upon increasing wall thickness, the model predicted a switch-type behavior of the Notch signaling state with a steep transition of synthetic toward contractile VSMCs at a certain transition thickness. These thicknesses varied per investigated arterial location and were in good agreement with human anatomical data, thereby suggesting that the Notch response to hemodynamics plays an important role in the establishment of vascular homeostasis. Twit Text FOAVip Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29610298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29610298 #FOAvip English Wikipedia <ref>{{Cite pmid|29610298 }}</ref> Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis #MMPMID29610298 Loerakker S ; Stassen OMJA ; Ter Huurne FM ; Boareto M ; Bouten CVC ; Sahlgren CM Proc Natl Acad Sci U S A 2018[Apr]; 115 (16 ): E3682-E3691 PMID29610298 show ga Hemodynamic forces and Notch signaling are both known as key regulators of arterial remodeling and homeostasis. However, how these two factors integrate in vascular morphogenesis and homeostasis is unclear. Here, we combined experiments and modeling to evaluate the impact of the integration of mechanics and Notch signaling on vascular homeostasis. Vascular smooth muscle cells (VSMCs) were cyclically stretched on flexible membranes, as quantified via video tracking, demonstrating that the expression of Jagged1, Notch3, and target genes was down-regulated with strain. The data were incorporated in a computational framework of Notch signaling in the vascular wall, where the mechanical load was defined by the vascular geometry and blood pressure. Upon increasing wall thickness, the model predicted a switch-type behavior of the Notch signaling state with a steep transition of synthetic toward contractile VSMCs at a certain transition thickness. These thicknesses varied per investigated arterial location and were in good agreement with human anatomical data, thereby suggesting that the Notch response to hemodynamics plays an important role in the establishment of vascular homeostasis. |Aged [MESH] |Arteries/ultrastructure [MESH] |Basic Helix-Loop-Helix Transcription Factors/biosynthesis/genetics [MESH] |Cell Cycle Proteins/biosynthesis/genetics [MESH] |Computer Simulation [MESH] |Endothelial Cells/metabolism [MESH] |Gene Expression Regulation [MESH] |Homeostasis [MESH] |Humans [MESH] |Jagged-1 Protein/biosynthesis/genetics/*physiology [MESH] |Ligands [MESH] |Mechanotransduction, Cellular/*physiology [MESH] |Middle Aged [MESH] |Models, Biological [MESH] |Morphogenesis/physiology [MESH] |Muscle Contraction/*physiology [MESH] |Muscle, Smooth, Vascular/*cytology/ultrastructure [MESH] |Myocytes, Smooth Muscle/*physiology [MESH] |Receptor, Notch3/biosynthesis/genetics/*physiology [MESH] |Repressor Proteins/biosynthesis/genetics [MESH] |Stress, Mechanical [MESH] |Transcription Factor HES-1/biosynthesis/genetics [MESH]Mechanosensitivity of Jagged-Notch signaling can induce a switch-type (epmc).pdf DeepDyve Pubget Overpricing