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10.1073/pnas.1707047115 http://scihub22266oqcxt.onion/10.1073/pnas.1707047115 C5910809!5910809!29610348     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (16): 4282-7 Nephropedia Template TP {{tp|p=29610348|t=2018. Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal |pdf=|usr=}}{{29610348}} gab.com Text Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29610348 #FOAvip Cigarette smoking is the leading cause of preventable disease and death in the United States. Severe withdrawal symptoms are the reason most people have a hard time quitting smoking. AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis and is activated in response to cellular stressors. We discovered that the AMPK pathway is activated following chronic nicotine use but is repressed following nicotine withdrawal. We reasoned that increasing pAMPK levels pharmacologically might reduce symptoms of nicotine withdrawal. After giving mice metformin, an AMPK activator, we were able to reduce nicotine withdrawal, and found that this was dependent on the presence of the AMPK protein in the hippocampus. This study suggests that AMPK activation could be a target for smoking cessation. Twit Text FOAVip Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29610348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29610348 #FOAvip English Wikipedia <ref>{{Cite pmid|29610348}}</ref> Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal #MMPMID29610348 Brynildsen JK; Lee BG; Perron IJ; Jin S; Kim SF; Blendy JA Proc Natl Acad Sci U S A 2018[Apr]; 115 (16): 4282-7 PMID29610348show ga Cigarette smoking is the leading cause of preventable disease and death in the United States. Severe withdrawal symptoms are the reason most people have a hard time quitting smoking. AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis and is activated in response to cellular stressors. We discovered that the AMPK pathway is activated following chronic nicotine use but is repressed following nicotine withdrawal. We reasoned that increasing pAMPK levels pharmacologically might reduce symptoms of nicotine withdrawal. After giving mice metformin, an AMPK activator, we were able to reduce nicotine withdrawal, and found that this was dependent on the presence of the AMPK protein in the hippocampus. This study suggests that AMPK activation could be a target for smoking cessation. äActivation of AMPK by metformin improves withdrawal signs precipitated(epmc).pdf DeepDyve Pubget Overpricing