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10.1038/s41598-018-24444-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-24444-6 C5910430!5910430 !29679017     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29679017 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 6341 Nephropedia Template TP {{tp|p=29679017 |t=2018. NF?B activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4 |pdf=|usr=}}{{29679017 }} gab.com Text NF B activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29679017 #FOAvip We have previously described that the NF?B pathway is upregulated during differentiation of glioblastoma stem-like cells (GSCs) which keeps differentiating GSCs in a proliferative astrocytic precursor state. However, extracellular signals and cellular mediators of this pathway are not clear yet. Here, we show that TLR4 is a key factor to promote NF?B activation in differentiating GSCs. TLR4 is upregulated during differentiation of GSCs and promotes transcriptional activation of NF?B as determined by luciferase-reporter assays and expression of NF?B target genes. Downregulation of TLR4 by shRNAs or blockade with anti-TLR4 specific antibodies drastically inhibited NF?B activity which promoted further differentiation and reduced proliferation of GSCs. We found that hyaluronic acid (HA), a main component of brain extracellular matrix, triggers the TLR4-NF?B pathway in differentiating GSCs. Moreover, HA is synthesized and released by GSCs undergoing differentiation and leads to transcriptional activation of NF?B, which is inhibited following downregulation of TLR4 or blockade of HA synthesis. Thus, we have demonstrated that during the process of differentiation, GSCs upregulate TLR4 and release the TLR4 ligand HA, which activates the TLR4-NF?B signaling pathway. This strategy may efficiently be used by differentiating GSCs to maintain their proliferative potential and consequently their tumorigenic capacity. Twit Text FOAVip NF B activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29679017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29679017 #FOAvip English Wikipedia <ref>{{Cite pmid|29679017 }}</ref> NF?B activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4 #MMPMID29679017 Ferrandez E ; Gutierrez O ; Segundo DS ; Fernandez-Luna JL Sci Rep 2018[Apr]; 8 (1 ): 6341 PMID29679017 show ga We have previously described that the NF?B pathway is upregulated during differentiation of glioblastoma stem-like cells (GSCs) which keeps differentiating GSCs in a proliferative astrocytic precursor state. However, extracellular signals and cellular mediators of this pathway are not clear yet. Here, we show that TLR4 is a key factor to promote NF?B activation in differentiating GSCs. TLR4 is upregulated during differentiation of GSCs and promotes transcriptional activation of NF?B as determined by luciferase-reporter assays and expression of NF?B target genes. Downregulation of TLR4 by shRNAs or blockade with anti-TLR4 specific antibodies drastically inhibited NF?B activity which promoted further differentiation and reduced proliferation of GSCs. We found that hyaluronic acid (HA), a main component of brain extracellular matrix, triggers the TLR4-NF?B pathway in differentiating GSCs. Moreover, HA is synthesized and released by GSCs undergoing differentiation and leads to transcriptional activation of NF?B, which is inhibited following downregulation of TLR4 or blockade of HA synthesis. Thus, we have demonstrated that during the process of differentiation, GSCs upregulate TLR4 and release the TLR4 ligand HA, which activates the TLR4-NF?B signaling pathway. This strategy may efficiently be used by differentiating GSCs to maintain their proliferative potential and consequently their tumorigenic capacity. |Brain Neoplasms/metabolism [MESH] |Cell Differentiation/genetics [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Gene Expression Regulation, Neoplastic/genetics [MESH] |Glioblastoma/metabolism [MESH] |Humans [MESH] |Hyaluronic Acid/metabolism/physiology [MESH] |NF-kappa B/*metabolism [MESH] |Neoplastic Stem Cells/*metabolism/physiology [MESH] |Signal Transduction/genetics [MESH]NF?B activation in differentiating glioblastoma stem-like cells is pro(epmc).pdf DeepDyve Pubget Overpricing