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10.1038/s41598-018-24706-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-24706-3 C5910418!5910418!29679061     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2018 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29679061|t=2018. The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier |pdf=|usr=}}{{29679061}} gab.com Text The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29679061 #FOAvip Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability. In these circumstances the diversity and content of gut microbiota in MIF-KO mice was considerably different compared to wild type mice. This change in microbiota was accompanied by an increased intestinal IgA concentration and a higher production of pro-inflammatory cytokines TNF and IFN-? in mesenteric lymph nodes of MIF-KO mice. The forced changes of microbiota executed by antibiotics prevented the ?leakage? of the barrier in MIF-KO mice, probably through up-regulation of occludin expression and normalization of cellular pore diameters. In addition, cytokine secretion was normalized after the treatment with antibiotics. These results suggest that MIF participates in the maintenance of physiological microbiota diversity and immunosurveillance, which in turn enables the proper intestinal barrier function. Twit Text FOAVip The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29679061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29679061 #FOAvip English Wikipedia <ref>{{Cite pmid|29679061}}</ref> The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier #MMPMID29679061 Vujicic M; Saksida T; Despotovic S; Bajic SS; Lali? I; Koprivica I; Gajic D; Golic N; Tolinacki M; Stojanovic I Sci Rep 2018[]; 8 (ä): ä PMID29679061show ga Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability. In these circumstances the diversity and content of gut microbiota in MIF-KO mice was considerably different compared to wild type mice. This change in microbiota was accompanied by an increased intestinal IgA concentration and a higher production of pro-inflammatory cytokines TNF and IFN-? in mesenteric lymph nodes of MIF-KO mice. The forced changes of microbiota executed by antibiotics prevented the ?leakage? of the barrier in MIF-KO mice, probably through up-regulation of occludin expression and normalization of cellular pore diameters. In addition, cytokine secretion was normalized after the treatment with antibiotics. These results suggest that MIF participates in the maintenance of physiological microbiota diversity and immunosurveillance, which in turn enables the proper intestinal barrier function. äThe Role of Macrophage Migration Inhibitory Factor in the Function of (epmc).pdf DeepDyve Pubget Overpricing