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10.1111/ajt.14645 http://scihub22266oqcxt.onion/10.1111/ajt.14645 C5910259!5910259!29314558     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2018 ; 18 (5): 1247-55 Nephropedia Template TP {{tp|p=29314558|t=2018. Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance |pdf=|usr=}}{{29314558}} gab.com Text Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29314558 #FOAvip The colony?stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1?mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil?derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response. Twit Text FOAVip Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=29314558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29314558 #FOAvip English Wikipedia <ref>{{Cite pmid|29314558}}</ref> Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance #MMPMID29314558 Braza MS; Conde P; Garcia M; Cortegano I; Brahmachary M; Pothula V; Fay F; Boros P; Werner SA; Ginhoux F; Mulder WJM; Ochando J Am J Transplant 2018[May]; 18 (5): 1247-55 PMID29314558show ga The colony?stimulating factor 1 (CSF1) regulates the differentiation and function of tissue macrophages and determines the outcome of the immune response. The molecular mechanisms behind CSF1?mediated macrophage development remain to be elucidated. Here we demonstrate that neutrophil?derived CSF1 controls macrophage polarization and proliferation, which is necessary for the induction of tolerance. Inhibiting neutrophil production of CSF1 or preventing macrophage proliferation, using targeted nanoparticles loaded with the cell cycle inhibitor simvastatin, abrogates the induction of tolerance. These results provide new mechanistic insights into the developmental requirements of tolerogenic macrophages and identify CSF1 producing neutrophils as critical regulators of the immunological response. äNeutrophil derived CSF1 induces macrophage polarization and promotes t(epmc).pdf DeepDyve Pubget Overpricing