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10.1007/s11882-016-0615-8 http://scihub22266oqcxt.onion/10.1007/s11882-016-0615-8 C5909980!5909980!27056559     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Allergy+Asthma+Rep 2016 ; 16 (5): 39 Nephropedia Template TP {{tp|p=27056559|t=2016. Gene Therapy for the Treatment of Primary Immune Deficiencies |pdf=|usr=}}{{27056559}} gab.com Text Gene Therapy for the Treatment of Primary Immune Deficiencies JO: Curr Allergy Asthma Rep http://www.kidney.de/pget.php?&tw=1&pmid=27056559 #FOAvip The use of gene therapy in the treatment of primary immune deficiencies (PID) has advanced significantly in the last decade. Clinical trials for X-linked severe combined immunodeficiency, adenosine deaminase deficiency (ADA), chronic granulomatous disease, and Wiskott-Aldrich syndrome have demonstrated that gene transfer into hematopoietic stem cells and autologous transplant can result in clinical improvement and is curative for many patients. Unfortunately, early clinical trials were complicated by vector-related insertional mutagenic events for several diseases with the exception of ADA-deficiency SCID. These results prompted the current wave of clinical trials for primary immunodeficiency using alternative retro- or lenti-viral vector constructs that are self-inactivating, and they have shown clinical efficacy without leukemic events thus far. The field of gene therapy continues to progress, with improvements in viral vector profiles, stem cell culturing techniques, and site-specific genome editing platforms. The future of gene therapy is promising, and we are quickly moving towards a time when it will be a standard cellular therapy for many forms of PID. Twit Text FOAVip Gene Therapy for the Treatment of Primary Immune Deficiencies ????Curr Allergy Asthma Rep http://www.kidney.de/pget.php?&tw=1&pmid=27056559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27056559 #FOAvip English Wikipedia <ref>{{Cite pmid|27056559}}</ref> Gene Therapy for the Treatment of Primary Immune Deficiencies #MMPMID27056559 Kuo CY; Kohn DB Curr Allergy Asthma Rep 2016[May]; 16 (5): 39 PMID27056559show ga The use of gene therapy in the treatment of primary immune deficiencies (PID) has advanced significantly in the last decade. Clinical trials for X-linked severe combined immunodeficiency, adenosine deaminase deficiency (ADA), chronic granulomatous disease, and Wiskott-Aldrich syndrome have demonstrated that gene transfer into hematopoietic stem cells and autologous transplant can result in clinical improvement and is curative for many patients. Unfortunately, early clinical trials were complicated by vector-related insertional mutagenic events for several diseases with the exception of ADA-deficiency SCID. These results prompted the current wave of clinical trials for primary immunodeficiency using alternative retro- or lenti-viral vector constructs that are self-inactivating, and they have shown clinical efficacy without leukemic events thus far. The field of gene therapy continues to progress, with improvements in viral vector profiles, stem cell culturing techniques, and site-specific genome editing platforms. The future of gene therapy is promising, and we are quickly moving towards a time when it will be a standard cellular therapy for many forms of PID. äGene Therapy for the Treatment of Primary Immune Deficiencies (epmc).pdf DeepDyve Pubget Overpricing