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10.1371/journal.pone.0192709 http://scihub22266oqcxt.onion/10.1371/journal.pone.0192709 C5909912!5909912!29677209     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (4): ä Nephropedia Template TP {{tp|p=29677209|t=2018. Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection |pdf=|usr=}}{{29677209}} gab.com Text Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29677209 #FOAvip The molecular mechanisms underlying susceptibility to severe respiratory syncytial virus (RSV) infection remain poorly understood. Herein, we report on the role of osteopontin (OPN) in regulation of RSV infection in human epithelial cells and how interleukin-1 beta (IL-1?), a cytokine secreted soon after RSV infection, when persistently expressed can induce OPN expression leading to increased viral infection. We first compared OPN expression in two human epithelial cell lines: HEK-293 and HEp-2. In contrast to HEp-2, HEK-293 expresses low levels of pro-caspase-1 resulting in decreased IL-1? expression in response to RSV infection. We found a correlation between low IL-1? levels and a delay in induction of OPN expression in RSV-infected HEK-293 cells compared to HEp-2. This phenomenon could partially explain the high susceptibility of HEp-2 cells to RSV infection versus the moderate susceptibility of HEK-293 cells. Also, HEK-293 cells expressing low levels of pro-caspase-1 exhibit decreased IL-1? expression and delayed OPN expression in response to RSV infection. HEK-293 cells incubated with human rIL-1? showed a dose-dependent increase in OPN expression upon RSV infection. Also, incubation with rOPN increased RSV viral load. Moreover, HEp-2 cells or mice infected with a mucogenic RSV strain RSV-L19F showed elevated levels of OPN in contrast to mice infected with the laboratory RSV strain rA2. This correlated with elevated levels of OPN following infection with RSV-L19F compared to rA2. Together, these results demonstrate that increased OPN expression is regulated in part by IL-1?, and the interplay between IL-1? and OPN signaling may play a pivotal role in the spread of RSV infection. Twit Text FOAVip Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29677209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29677209 #FOAvip English Wikipedia <ref>{{Cite pmid|29677209}}</ref> Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection #MMPMID29677209 Sampayo-Escobar V; Green R; Cheung MB; Bedi R; Mohapatra S; Mohapatra SS PLoS One 2018[]; 13 (4): ä PMID29677209show ga The molecular mechanisms underlying susceptibility to severe respiratory syncytial virus (RSV) infection remain poorly understood. Herein, we report on the role of osteopontin (OPN) in regulation of RSV infection in human epithelial cells and how interleukin-1 beta (IL-1?), a cytokine secreted soon after RSV infection, when persistently expressed can induce OPN expression leading to increased viral infection. We first compared OPN expression in two human epithelial cell lines: HEK-293 and HEp-2. In contrast to HEp-2, HEK-293 expresses low levels of pro-caspase-1 resulting in decreased IL-1? expression in response to RSV infection. We found a correlation between low IL-1? levels and a delay in induction of OPN expression in RSV-infected HEK-293 cells compared to HEp-2. This phenomenon could partially explain the high susceptibility of HEp-2 cells to RSV infection versus the moderate susceptibility of HEK-293 cells. Also, HEK-293 cells expressing low levels of pro-caspase-1 exhibit decreased IL-1? expression and delayed OPN expression in response to RSV infection. HEK-293 cells incubated with human rIL-1? showed a dose-dependent increase in OPN expression upon RSV infection. Also, incubation with rOPN increased RSV viral load. Moreover, HEp-2 cells or mice infected with a mucogenic RSV strain RSV-L19F showed elevated levels of OPN in contrast to mice infected with the laboratory RSV strain rA2. This correlated with elevated levels of OPN following infection with RSV-L19F compared to rA2. Together, these results demonstrate that increased OPN expression is regulated in part by IL-1?, and the interplay between IL-1? and OPN signaling may play a pivotal role in the spread of RSV infection. äOsteopontin plays a pivotal role in increasing severity of respiratory(epmc).pdf DeepDyve Pubget Overpricing