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10.1093/nar/gky093 http://scihub22266oqcxt.onion/10.1093/nar/gky093 C5909450!5909450!29438503     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29438503.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2018 ; 46 (7): 3351-65 Nephropedia Template TP {{tp|p=29438503|t=2018. Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation |pdf=|usr=}}{{29438503}} gab.com Text Lineage specific transcription factors and epigenetic regulators mediate TGF -dependent enhancer activation JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=29438503 #FOAvip During neurogenesis, dynamic developmental cues, transcription factors and histone modifying enzymes regulate the gene expression programs by modulating the activity of neural-specific enhancers. How transient developmental signals coordinate transcription factor recruitment to enhancers and to which extent chromatin modifiers contribute to enhancer activity is starting to be uncovered. Here, we take advantage of neural stem cells as a model to unravel the mechanisms underlying neural enhancer activation in response to the TGF? signaling. Genome-wide experiments demonstrate that the proneural factor ASCL1 assists SMAD3 in the binding to a subset of enhancers. Once located at the enhancers, SMAD3 recruits the histone demethylase JMJD3 and the remodeling factor CHD8, creating the appropriate chromatin landscape to allow enhancer transcription and posterior gene activation. Finally, to analyze the phenotypical traits owed to cis-regulatory regions, we use CRISPR?Cas9 technology to demonstrate that the TGF?-responsive Neurog2 enhancer is essential for proper neuronal polarization. Twit Text FOAVip Lineage specific transcription factors and epigenetic regulators mediate TGF -dependent enhancer activation ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=29438503 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29438503 #FOAvip English Wikipedia <ref>{{Cite pmid|29438503}}</ref> Lineage specific transcription factors and epigenetic regulators mediate TGF?-dependent enhancer activation #MMPMID29438503 Fueyo R; Iacobucci S; Pappa S; Estarás C; Lois S; Vicioso-Mantis M; Navarro C; Cruz-Molina S; Reyes JC; Rada-Iglesias Á; de la Cruz X; Martínez-Balbás MA Nucleic Acids Res 2018[Apr]; 46 (7): 3351-65 PMID29438503show ga During neurogenesis, dynamic developmental cues, transcription factors and histone modifying enzymes regulate the gene expression programs by modulating the activity of neural-specific enhancers. How transient developmental signals coordinate transcription factor recruitment to enhancers and to which extent chromatin modifiers contribute to enhancer activity is starting to be uncovered. Here, we take advantage of neural stem cells as a model to unravel the mechanisms underlying neural enhancer activation in response to the TGF? signaling. Genome-wide experiments demonstrate that the proneural factor ASCL1 assists SMAD3 in the binding to a subset of enhancers. Once located at the enhancers, SMAD3 recruits the histone demethylase JMJD3 and the remodeling factor CHD8, creating the appropriate chromatin landscape to allow enhancer transcription and posterior gene activation. Finally, to analyze the phenotypical traits owed to cis-regulatory regions, we use CRISPR?Cas9 technology to demonstrate that the TGF?-responsive Neurog2 enhancer is essential for proper neuronal polarization. äLineage specific transcription factors and epigenetic regulators media(epmc).pdf DeepDyve Pubget Overpricing