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10.1038/s41598-018-24565-y http://scihub22266oqcxt.onion/10.1038/s41598-018-24565-y C5908909!5908909 !29674691     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29674691 &cmd=llinks): Failed to open stream: HTTP request failed! 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Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation |pdf=|usr=}}{{29674691 }} gab.com Text Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29674691 #FOAvip Aloperine is a quinolizidine alkaloid extracted from Sophora alopecuroides. It has been proven to alleviate oxidative stress and effectively promote tumor cell apoptosis in mice. Herein, we investigated whether aloperine could also mediate its protective effects on bleomycin (BLM)-induced pulmonary fibrosis. Pathological staining, western blot, RT-PCR and flow cytometry were used to evaluate the impact of aloperine on the development of pulmonary fibrosis. The effect of aloperine on fibroblast proliferation, differentiation and related signaling pathways were next investigated to demonstrate the underlying mechanisms. In the present report, we showed that aloperine provided protection for mice against BLM-induced pulmonary fibrosis as manifested by the attenuated lung injury and reduced fibrosis along with alleviated fibroblast proliferation and differentiation. Additionally, we provided in vitro evidence revealing that aloperine inhibited cellular proliferation in PDGF-BB-stimulated mouse lung fibroblasts by repressed PI3K/AKT/mTOR signaling and fibroblast to myofibroblast differentiation by repressed TGF-?/Smad signaling. Overall, our data showed that aloperine could protect the mice against BLM-induced pulmonary fibrosis by attenuated fibroblast proliferation and differentiation, which indicated that aloperine may be therapeutically beneficial for IPF patients. Twit Text FOAVip Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29674691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29674691 #FOAvip English Wikipedia <ref>{{Cite pmid|29674691 }}</ref> Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuating Fibroblast Proliferation and Differentiation #MMPMID29674691 Yin W ; Han J ; Zhang Z ; Han Z ; Wang S Sci Rep 2018[Apr]; 8 (1 ): 6265 PMID29674691 show ga Aloperine is a quinolizidine alkaloid extracted from Sophora alopecuroides. It has been proven to alleviate oxidative stress and effectively promote tumor cell apoptosis in mice. Herein, we investigated whether aloperine could also mediate its protective effects on bleomycin (BLM)-induced pulmonary fibrosis. Pathological staining, western blot, RT-PCR and flow cytometry were used to evaluate the impact of aloperine on the development of pulmonary fibrosis. The effect of aloperine on fibroblast proliferation, differentiation and related signaling pathways were next investigated to demonstrate the underlying mechanisms. In the present report, we showed that aloperine provided protection for mice against BLM-induced pulmonary fibrosis as manifested by the attenuated lung injury and reduced fibrosis along with alleviated fibroblast proliferation and differentiation. Additionally, we provided in vitro evidence revealing that aloperine inhibited cellular proliferation in PDGF-BB-stimulated mouse lung fibroblasts by repressed PI3K/AKT/mTOR signaling and fibroblast to myofibroblast differentiation by repressed TGF-?/Smad signaling. Overall, our data showed that aloperine could protect the mice against BLM-induced pulmonary fibrosis by attenuated fibroblast proliferation and differentiation, which indicated that aloperine may be therapeutically beneficial for IPF patients. |Animals [MESH] |Bleomycin/*adverse effects [MESH] |Cell Differentiation/*drug effects [MESH] |Cell Proliferation/*drug effects [MESH] |Fibroblasts/*pathology [MESH] |Mice [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Piperidines/*therapeutic use [MESH] |Pulmonary Fibrosis/*chemically induced [MESH] |Quinolizidines [MESH] |Signal Transduction/drug effects [MESH]Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis b(epmc).pdf DeepDyve Pubget Overpricing