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10.1038/s41598-018-24749-6 http://scihub22266oqcxt.onion/10.1038/s41598-018-24749-6 C5908876!5908876 !29674727     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29674727 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 6277 Nephropedia Template TP {{tp|p=29674727 |t=2018. Acute Hyperthermia Inhibits TGF-?1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling |pdf=|usr=}}{{29674727 }} gab.com Text Acute Hyperthermia Inhibits TGF- 1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29674727 #FOAvip Transforming growth factor-?1 (TGF-?1) induces phenotypic changes in fibroblasts to become myofibroblasts with increased production of extracellular matrix (ECM) components and cytokines. It is also known that excessive activation of myofibroblasts accelerates cardiac fibrosis, remodeling, and thus cardiac dysfunction. However, no effective therapy has been established to prevent this process although recent clinical studies have demonstrated the effectiveness of hyperthermia in cardiac dysfunction. The aim of this study was to examine the molecular mechanism of hyperthermia on TGF-?1-mediated phenotypic changes in cardiac fibroblasts. TGF-?1 increased the expression of IL-6, ?-smooth muscle actin (?-SMA), and collagen in human cardiac fibroblasts (HCFs). Hyperthermia (42?°C) significantly prevented these changes, i.e., increases in IL-6, ?-SMA, and collagen, as induced by TGF-?1 in a time-dependent manner. Immunoblotting showed that hyperthermia decreased Akt/S6K signaling, but did not affect Smad2 and Smad3 signaling. Pharmacological inhibition of Akt signaling mimicked these effects of hyperthermia. Furthermore, hyperthermia treatment prevented cardiac fibrosis in Ang II infusion mice model. Putting together, our findings suggest that hyperthermia directly inhibits TGF-?-mediated activation of HCFs via suppressing Akt/S6K signaling. Twit Text FOAVip Acute Hyperthermia Inhibits TGF- 1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29674727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29674727 #FOAvip English Wikipedia <ref>{{Cite pmid|29674727 }}</ref> Acute Hyperthermia Inhibits TGF-?1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling #MMPMID29674727 Narikawa M ; Umemura M ; Tanaka R ; Fujita T ; Yokoyama U ; Ishigami T ; Kimura K ; Tamura K ; Ishikawa Y Sci Rep 2018[Apr]; 8 (1 ): 6277 PMID29674727 show ga Transforming growth factor-?1 (TGF-?1) induces phenotypic changes in fibroblasts to become myofibroblasts with increased production of extracellular matrix (ECM) components and cytokines. It is also known that excessive activation of myofibroblasts accelerates cardiac fibrosis, remodeling, and thus cardiac dysfunction. However, no effective therapy has been established to prevent this process although recent clinical studies have demonstrated the effectiveness of hyperthermia in cardiac dysfunction. The aim of this study was to examine the molecular mechanism of hyperthermia on TGF-?1-mediated phenotypic changes in cardiac fibroblasts. TGF-?1 increased the expression of IL-6, ?-smooth muscle actin (?-SMA), and collagen in human cardiac fibroblasts (HCFs). Hyperthermia (42?°C) significantly prevented these changes, i.e., increases in IL-6, ?-SMA, and collagen, as induced by TGF-?1 in a time-dependent manner. Immunoblotting showed that hyperthermia decreased Akt/S6K signaling, but did not affect Smad2 and Smad3 signaling. Pharmacological inhibition of Akt signaling mimicked these effects of hyperthermia. Furthermore, hyperthermia treatment prevented cardiac fibrosis in Ang II infusion mice model. Putting together, our findings suggest that hyperthermia directly inhibits TGF-?-mediated activation of HCFs via suppressing Akt/S6K signaling. |*Signal Transduction [MESH] |Actins/metabolism [MESH] |Acute Disease [MESH] |Angiotensin II/administration & dosage [MESH] |Animals [MESH] |Disease Models, Animal [MESH] |Fever/enzymology/*metabolism/pathology [MESH] |Fibroblasts/*metabolism [MESH] |Humans [MESH] |Interleukin-6/biosynthesis/genetics [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myocardium/cytology/*metabolism [MESH] |Proto-Oncogene Proteins c-akt/*metabolism [MESH] |RNA, Messenger/genetics [MESH]Acute Hyperthermia Inhibits TGF-?1-induced Cardiac Fibroblast Activati(epmc).pdf DeepDyve Pubget Overpricing