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10.1093/jmcb/mjx005 http://scihub22266oqcxt.onion/10.1093/jmcb/mjx005 C5907835!5907835!28096292     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Cell+Biol 2017 ; 9 (1): 26-33 Nephropedia Template TP {{tp|p=28096292|t=2017. Regulation of kidney development by the Mdm2/Mdm4?p53 axis |pdf=|usr=}}{{28096292}} gab.com Text Regulation of kidney development by the Mdm2/Mdm4 p53 axis JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28096292 #FOAvip While p53 activity is required for tumour suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a tight control on p53 activity during this period. The critical role of the negative regulators of p53, Mdm2 and Mdm4, in vertebrate development came to light by fatal disruption of embryogenesis that was observed with Mdm2 and Mdm4 gene deletions in mice. Embryonic lethality was rescued only by superimposing p53 removal. Here we summarize the contribution of the Mdm2/Mdm4?p53 axis that occurs at multiple steps of kidney development. Conditional, cell type-specific deletions reveal distinct functions of these proteins in renal morphogenesis. The severe impact on the renal phenotype from targeted gene deletions underscores the critical role played by the Mdm2/Mdm4?p53 nexus on nephrogenesis, and emphasizes the need to monitor patients with aberrations in this pathway for kidney function defects and associated cardiovascular dysfunction. Twit Text FOAVip Regulation of kidney development by the Mdm2/Mdm4 p53 axis ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28096292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28096292 #FOAvip English Wikipedia <ref>{{Cite pmid|28096292}}</ref> Regulation of kidney development by the Mdm2/Mdm4?p53 axis #MMPMID28096292 El-Dahr S; Hilliard S; Saifudeen Z J Mol Cell Biol 2017[Feb]; 9 (1): 26-33 PMID28096292show ga While p53 activity is required for tumour suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a tight control on p53 activity during this period. The critical role of the negative regulators of p53, Mdm2 and Mdm4, in vertebrate development came to light by fatal disruption of embryogenesis that was observed with Mdm2 and Mdm4 gene deletions in mice. Embryonic lethality was rescued only by superimposing p53 removal. Here we summarize the contribution of the Mdm2/Mdm4?p53 axis that occurs at multiple steps of kidney development. Conditional, cell type-specific deletions reveal distinct functions of these proteins in renal morphogenesis. The severe impact on the renal phenotype from targeted gene deletions underscores the critical role played by the Mdm2/Mdm4?p53 nexus on nephrogenesis, and emphasizes the need to monitor patients with aberrations in this pathway for kidney function defects and associated cardiovascular dysfunction. äRegulation of kidney development by the Mdm2/Mdm4?p53 axis (epmc).pdf DeepDyve Pubget Overpricing