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10.14814/phy2.13670 http://scihub22266oqcxt.onion/10.14814/phy2.13670 C5907819!5907819!29671959     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rep 2018 ; 6 (8): ä Nephropedia Template TP {{tp|p=29671959|t=2018. Renal sulfate reabsorption in healthy individuals and renal transplant recipients |pdf=|usr=}}{{29671959}} gab.com Text Renal sulfate reabsorption in healthy individuals and renal transplant recipients JO: Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29671959 #FOAvip Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as renal transplant recipients (RTR). Hence, we aimed to assess sulfate reabsorption in kidney donors and RTR. Plasma and urinary sulfate were determined in 671 RTR and in 251 kidney donors. Tubular sulfate reabsorption (TSR) was defined as filtered load minus sulfate excretion and fractional sulfate reabsorption (FSR) was defined as 1?fractional excretion. Linear regression analyses were employed to explore associations of FSR with baseline parameters and to identify the determinants of FSR in RTR. Compared to kidney donors, RTR had significantly lower TSR (15.2 [11.2?19.5] vs. 20.3 [16.7?26.3] ?mol/min), and lower FSR (0.56 [0.48?0.64] vs. 0.64 [0.57?0.69]) (all P < 0.001). Kidney donation reduced both TSR and FSR by circa 50% and 25% respectively (both P < 0.001). In RTR and donors, both TSR and FSR associated positively with renal function. In RTR, FSR was independently associated with urinary thiosulfate (? = ?0.18; P = 0.002), growth hormone (? = 0.12; P = 0.007), the intakes of alcohol (? = ?0.14; P = 0.002), methionine (? = ?0.34; P < 0.001), cysteine (? = ?0.41; P < 0.001), and vitamin D (? = ?0.14; P = 0.009). In conclusion, TSR and FSR are lower in RTR compared to kidney donors and both associated with renal function. Additionally, FSR is determined by various dietary and metabolic factors. Future research should determine the mechanisms behind sulfate handling in humans and the prognostic value of renal sulfate reabsorption in RTR. Twit Text FOAVip Renal sulfate reabsorption in healthy individuals and renal transplant recipients ????Physiol Rep http://www.kidney.de/pget.php?&tw=1&pmid=29671959 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29671959 #FOAvip English Wikipedia <ref>{{Cite pmid|29671959}}</ref> Renal sulfate reabsorption in healthy individuals and renal transplant recipients #MMPMID29671959 Post A; Minovi? I; van den Berg E; Eggersdorfer ML; Navis GJ; Geleijnse JM; Gans ROB; van Goor H; Struck J; Franssen CFM; Kema IP; Bakker SJL Physiol Rep 2018[Apr]; 6 (8): ä PMID29671959show ga Inorganic sulfate is essential for normal cellular function and its homeostasis is primarily regulated in the kidneys. However, little is known about renal sulfate handling in humans and particularly in populations with impaired kidney function such as renal transplant recipients (RTR). Hence, we aimed to assess sulfate reabsorption in kidney donors and RTR. Plasma and urinary sulfate were determined in 671 RTR and in 251 kidney donors. Tubular sulfate reabsorption (TSR) was defined as filtered load minus sulfate excretion and fractional sulfate reabsorption (FSR) was defined as 1?fractional excretion. Linear regression analyses were employed to explore associations of FSR with baseline parameters and to identify the determinants of FSR in RTR. Compared to kidney donors, RTR had significantly lower TSR (15.2 [11.2?19.5] vs. 20.3 [16.7?26.3] ?mol/min), and lower FSR (0.56 [0.48?0.64] vs. 0.64 [0.57?0.69]) (all P < 0.001). Kidney donation reduced both TSR and FSR by circa 50% and 25% respectively (both P < 0.001). In RTR and donors, both TSR and FSR associated positively with renal function. In RTR, FSR was independently associated with urinary thiosulfate (? = ?0.18; P = 0.002), growth hormone (? = 0.12; P = 0.007), the intakes of alcohol (? = ?0.14; P = 0.002), methionine (? = ?0.34; P < 0.001), cysteine (? = ?0.41; P < 0.001), and vitamin D (? = ?0.14; P = 0.009). In conclusion, TSR and FSR are lower in RTR compared to kidney donors and both associated with renal function. Additionally, FSR is determined by various dietary and metabolic factors. Future research should determine the mechanisms behind sulfate handling in humans and the prognostic value of renal sulfate reabsorption in RTR. äRenal sulfate reabsorption in healthy individuals and renal transplant(epmc).pdf DeepDyve Pubget Overpricing