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2018 ; 18
(1
): 438
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Effect of metformin use on the risk and prognosis of endometrial cancer: a
systematic review and meta-analysis
#MMPMID29669520
Chu D
; Wu J
; Wang K
; Zhao M
; Wang C
; Li L
; Guo R
BMC Cancer
2018[Apr]; 18
(1
): 438
PMID29669520
show ga
BACKGROUND: Previous studies have suggested that metformin may be useful for
preventing and treating endometrial cancer (EC), while the results have been
inconsistent. This systematic review and meta-analysis aimed to investigate the
association between metformin use and risk and prognosis of patients with EC.
METHODS: PubMed, Embase, and the Cochrane Library databases were searched for
observational studies evaluating the effect of metformin on EC prevention or
treatment. The odds ratio (OR) was used for analyzing risks, and the hazard ratio
(HR) was used for analyzing survival outcomes. A random-effects model was used
for data analysis. RESULTS: Seven studies reported data on EC risk. The pooled
results suggested that metformin was not significantly associated with a lower
risk of EC [OR = 1.05, 95% confidence interval (CI) 0.82-1.35, P = 0.70]. For
patients with diabetes, metformin showed no advantage in reducing the EC risk
compared with other interventions (OR = 0.99, 95% CI 0.78-1.26, P = 0.95).
Further, seven studies were included for survival analysis. The pooled data
showed that metformin could significantly improve the overall survival of
patients with EC (HR = 0.61, 95% CI 0.48-0.77, P < 0.05) and reduce the risk of
EC recurrence (OR = 0.50, 95% CI 0.28-0.92, P < 0.05) Finally, we noted metformin
was associated with significantly improving the overall survival of EC patients
among diabetes (HR = 0.47; 95%CI 0.33-0.67, P < 0.05). CONCLUSIONS: This
meta-analysis did not prove that metformin was beneficial for preventing EC.
However, metformin could prolong the overall survival of patients with EC and
reduce their risk of cancer relapse.
|Endometrial Neoplasms/*mortality/pathology/prevention & control
[MESH]
free
free
free
