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2018 ; 28
(5
): 1898-1909
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Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment
3D Space in a Hierarchical Manner
#MMPMID29554231
Kim M
; Maguire EA
Cereb Cortex
2018[May]; 28
(5
): 1898-1909
PMID29554231
show ga
Humans commonly operate within 3D environments such as multifloor buildings and
yet there is a surprising dearth of studies that have examined how these spaces
are represented in the brain. Here, we had participants learn the locations of
paintings within a virtual multilevel gallery building and then used behavioral
tests and fMRI repetition suppression analyses to investigate how this 3D
multicompartment space was represented, and whether there was a bias in encoding
vertical and horizontal information. We found faster response times for
within-room egocentric spatial judgments and behavioral priming effects of
visiting the same room, providing evidence for a compartmentalized representation
of space. At the neural level, we observed a hierarchical encoding of 3D spatial
information, with left anterior hippocampus representing local information within
a room, while retrosplenial cortex, parahippocampal cortex, and posterior
hippocampus represented room information within the wider building. Of note, both
our behavioral and neural findings showed that vertical and horizontal location
information was similarly encoded, suggesting an isotropic representation of 3D
space even in the context of a multicompartment environment. These findings
provide much-needed information about how the human brain supports spatial memory
and navigation in buildings with numerous levels and rooms.