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10.1093/cercor/bhy054

http://scihub22266oqcxt.onion/10.1093/cercor/bhy054
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C5907342!5907342 !29554231
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suck abstract from ncbi


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pmid29554231
      Cereb+Cortex 2018 ; 28 (5 ): 1898-1909
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  • Hippocampus, Retrosplenial and Parahippocampal Cortices Encode Multicompartment 3D Space in a Hierarchical Manner #MMPMID29554231
  • Kim M ; Maguire EA
  • Cereb Cortex 2018[May]; 28 (5 ): 1898-1909 PMID29554231 show ga
  • Humans commonly operate within 3D environments such as multifloor buildings and yet there is a surprising dearth of studies that have examined how these spaces are represented in the brain. Here, we had participants learn the locations of paintings within a virtual multilevel gallery building and then used behavioral tests and fMRI repetition suppression analyses to investigate how this 3D multicompartment space was represented, and whether there was a bias in encoding vertical and horizontal information. We found faster response times for within-room egocentric spatial judgments and behavioral priming effects of visiting the same room, providing evidence for a compartmentalized representation of space. At the neural level, we observed a hierarchical encoding of 3D spatial information, with left anterior hippocampus representing local information within a room, while retrosplenial cortex, parahippocampal cortex, and posterior hippocampus represented room information within the wider building. Of note, both our behavioral and neural findings showed that vertical and horizontal location information was similarly encoded, suggesting an isotropic representation of 3D space even in the context of a multicompartment environment. These findings provide much-needed information about how the human brain supports spatial memory and navigation in buildings with numerous levels and rooms.
  • |*Imaging, Three-Dimensional [MESH]
  • |*Social Dominance [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Analysis of Variance [MESH]
  • |Egocentrism [MESH]
  • |Female [MESH]
  • |Hippocampus/*diagnostic imaging [MESH]
  • |Humans [MESH]
  • |Judgment/physiology [MESH]
  • |Magnetic Resonance Imaging [MESH]
  • |Male [MESH]
  • |Memory/*physiology [MESH]
  • |Neural Pathways/*diagnostic imaging [MESH]
  • |Oxygen/blood [MESH]
  • |Parahippocampal Gyrus/*diagnostic imaging [MESH]
  • |Space Perception [MESH]
  • |User-Computer Interface [MESH]


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