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10.1038/s41598-018-24356-5 http://scihub22266oqcxt.onion/10.1038/s41598-018-24356-5 C5906673!5906673 !29670184     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29670184 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1? and survivin suppression |pdf=|usr=}}{{29670184 }} gab.com Text Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1 and survivin suppression JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29670184 #FOAvip Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1?, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs. In sinonasal specimens from patients with CRS, HIF-1? and survivin were up-regulated in eosinophils from patients with NPs compared with levels in patients without NPs. Under hypoxia, HIF-1? and survivin expression was up-regulated in EoL-1 cells. Wogonin down-regulated both HIF-1? and survivin in EoL-1 cells. In addition, overexpression of survivin protected EoL-1 cells against apoptosis in response to wogonin. Moreover, wogonin attenuated nasal polyp formation in a murine model. Our findings suggest that wogonin could induce caspase-3 activation by suppressing HIF-1? and survivin expression in EoL-1 cells. Further studies regarding novel therapeutic options for CRSwNP targeting eosinophil apoptosis are needed. Twit Text FOAVip Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1 and survivin suppression ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29670184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29670184 #FOAvip English Wikipedia <ref>{{Cite pmid|29670184 }}</ref> Wogonin attenuates nasal polyp formation by inducing eosinophil apoptosis through HIF-1? and survivin suppression #MMPMID29670184 Khalmuratova R ; Lee M ; Mo JH ; Jung Y ; Park JW ; Shin HW Sci Rep 2018[Apr]; 8 (1 ): 6201 PMID29670184 show ga Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is an inflammatory sinonasal disorder characterized by eosinophilic inflammation and T-helper 2 skewing. Eosinophil accumulation in sinonasal mucosa comprises a major feature of CRSwNP. The study aimed to investigate the effect of the flavone wogonin in nasal polyposis by assessing its ability to induce eosinophil apoptosis in vitro and attenuate eosinophilic CRSwNP in mice. Double immunofluorescence, immunohistochemistry, flow cytometry, and immunoblotting were performed to evaluate hypoxia-inducible factor (HIF)-1?, survivin, and apoptotic markers in the human eosinophilic EoL-1 cell line or sinonasal tissues from patients with CRS with or without NPs. In sinonasal specimens from patients with CRS, HIF-1? and survivin were up-regulated in eosinophils from patients with NPs compared with levels in patients without NPs. Under hypoxia, HIF-1? and survivin expression was up-regulated in EoL-1 cells. Wogonin down-regulated both HIF-1? and survivin in EoL-1 cells. In addition, overexpression of survivin protected EoL-1 cells against apoptosis in response to wogonin. Moreover, wogonin attenuated nasal polyp formation in a murine model. Our findings suggest that wogonin could induce caspase-3 activation by suppressing HIF-1? and survivin expression in EoL-1 cells. Further studies regarding novel therapeutic options for CRSwNP targeting eosinophil apoptosis are needed. |Adult [MESH] |Aged [MESH] |Airway Remodeling [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |Biomarkers [MESH] |Caspase 3/genetics/metabolism [MESH] |Cell Line [MESH] |Cytokines/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Eosinophils/*drug effects/*metabolism [MESH] |Female [MESH] |Flavanones/*pharmacology [MESH] |Fluorescent Antibody Technique [MESH] |Gene Expression [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors/genetics/metabolism [MESH] |Immunohistochemistry [MESH] |Inflammation/etiology/metabolism/pathology [MESH] |Leukocyte Count [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Middle Aged [MESH] |Nasal Polyps/drug therapy/*etiology/*metabolism/pathology [MESH] |Protein Binding [MESH]Wogonin attenuates nasal polyp formation by inducing eosinophil apopto(epmc).pdf DeepDyve Pubget Overpricing