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10.1111/apt.13620 http://scihub22266oqcxt.onion/10.1111/apt.13620 C5906100!5906100!27061197     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27061197&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aliment+Pharmacol+Ther 2016 ; 43 (11): 1109-23 Nephropedia Template TP {{tp|p=27061197|t=2016. Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis |pdf=|usr=}}{{27061197}} gab.com Text Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis JO: Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27061197 #FOAvip Background: Non-alcoholic fatty liver disease (NAFLD) can lead to non-alcoholic steato-hepatitis (NASH) and cirrhosis. Fibrosis predicts worse outcomes and mortality. New treatments targeting fibrosis are being investigated to reverse disease progression. Aim: To review the new pipeline therapeutic agents targeting fibrosis in NASH patients, with particular focus on clinical trials in which reversing fibrosis and portal hypertension are the primary outcomes. Methods: The literature was searched in PubMed between January 2000 and January 2016 using search terms non-alcoholic fatty liver disease and NASH, with filters of ?English language?. We focused on fibrosis improvement as the key outcome. We also searched the ClinicalTrials.gov for promising agents that target fibrosis in NASH patients. Results: Significant advances have been made on approaches targeting fibrosis in NASH patients. Many therapeutic agents are already in development, some of which have shown promising results in preclinical and phase I studies. Novel therapies have entered phase II and III studies targeting fibrosis reversal and/or improvement in portal hypertension. Innovative studies have also started looking into combining these agents, aiming at different mechanisms to maximise therapeutic outcomes. We found five clinical trials in phase II and one in phase III focusing on fibrosis in NASH patients as key outcomes. One of the phase II trials is using combination therapy to target fibrosis. Conclusions: Ongoing research studies are already investigating new pathways aimed at reversing fibrosis in NASH patients. Novel therapeutic agents are in development and are expected to offer unique options to NASH patients with advanced fibrosis. Twit Text FOAVip Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis ????Aliment Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27061197 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27061197 #FOAvip English Wikipedia <ref>{{Cite pmid|27061197}}</ref> Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis #MMPMID27061197 Noureddin M; Anstee QM; Loomba R Aliment Pharmacol Ther 2016[Jun]; 43 (11): 1109-23 PMID27061197show ga Background: Non-alcoholic fatty liver disease (NAFLD) can lead to non-alcoholic steato-hepatitis (NASH) and cirrhosis. Fibrosis predicts worse outcomes and mortality. New treatments targeting fibrosis are being investigated to reverse disease progression. Aim: To review the new pipeline therapeutic agents targeting fibrosis in NASH patients, with particular focus on clinical trials in which reversing fibrosis and portal hypertension are the primary outcomes. Methods: The literature was searched in PubMed between January 2000 and January 2016 using search terms non-alcoholic fatty liver disease and NASH, with filters of ?English language?. We focused on fibrosis improvement as the key outcome. We also searched the ClinicalTrials.gov for promising agents that target fibrosis in NASH patients. Results: Significant advances have been made on approaches targeting fibrosis in NASH patients. Many therapeutic agents are already in development, some of which have shown promising results in preclinical and phase I studies. Novel therapies have entered phase II and III studies targeting fibrosis reversal and/or improvement in portal hypertension. Innovative studies have also started looking into combining these agents, aiming at different mechanisms to maximise therapeutic outcomes. We found five clinical trials in phase II and one in phase III focusing on fibrosis in NASH patients as key outcomes. One of the phase II trials is using combination therapy to target fibrosis. Conclusions: Ongoing research studies are already investigating new pathways aimed at reversing fibrosis in NASH patients. Novel therapeutic agents are in development and are expected to offer unique options to NASH patients with advanced fibrosis. äReview article: emerging anti-fibrotic therapies in the treatment of n(epmc).pdf DeepDyve Pubget Overpricing