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10.1093/ajh/hpy009 http://scihub22266oqcxt.onion/10.1093/ajh/hpy009 C5905655!5905655!29342227     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hypertens 2018 ; 31 (5): 622-9 Nephropedia Template TP {{tp|p=29342227|t=2018. Brain Cytosolic Phospholipase A2? Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice |pdf=|usr=}}{{29342227}} gab.com Text Brain Cytosolic Phospholipase A2 Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice JO: Am J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=29342227 #FOAvip BACKGROUND: Recently, we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2? (cPLA2?) via production of prohypertensive eicosanoids. Since Ang II increases blood pressure (BP) via its action in the subfornical organ (SFO), it led us to investigate the expression and possible contribution of cPLA2? to oxidative stress and development of hypertension in this brain area. METHODS: Adenovirus (Ad)-green fluorescence protein (GFP) cPLA2? short hairpin (sh) RNA (Ad-cPLA2? shRNA) and its control Ad-scrambled shRNA (Ad-Scr shRNA) or Ad-enhanced cyan fluorescence protein cPLA2? DNA (Ad-cPLA2? DNA) and its control Ad-GFP DNA were transduced into SFO of cPLA2?+/+ and cPLA2??/? male mice, respectively. Ang II (700 ng/kg/min) was infused for 14 days in these mice, and BP was measured by tail-cuff and radio telemetry. cPLA2 activity, reactive oxygen species production, and endoplasmic reticulum stress were measured in the SFO. RESULTS: Transduction of SFO with Ad-cPLA2? shRNA, but not Ad-Scr shRNA in cPLA2?+/+ mice, minimized expression of cPLA2?, Ang II-induced cPLA2? activity and oxidative stress in the SFO, BP, and cardiac and renal fibrosis. In contrast, Ad-cPLA2? DNA, but not its control Ad-GFP DNA in cPLA2??/? mice, restored the expression of cPLA2?, and Ang II-induced increase in cPLA2 activity and oxidative stress in the SFO, BP, cardiac, and renal fibrosis. CONCLUSIONS: These data suggest that cPLA2? in the SFO is crucial in mediating Ang II-induced hypertension and associated pathogenesis. Therefore, development of selective cPLA2? inhibitors could be useful in treating hypertension and its pathogenesis. Twit Text FOAVip Brain Cytosolic Phospholipase A2 Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice ????Am J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=29342227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29342227 #FOAvip English Wikipedia <ref>{{Cite pmid|29342227}}</ref> Brain Cytosolic Phospholipase A2? Mediates Angiotensin II-Induced Hypertension and Reactive Oxygen Species Production in Male Mice #MMPMID29342227 Song CY; Khan NS; Liao FF; Wang B; Shin JS; Bonventre JV; Malik KU Am J Hypertens 2018[Apr]; 31 (5): 622-9 PMID29342227show ga BACKGROUND: Recently, we reported that angiotensin II (Ang II)-induced hypertension is mediated by group IV cytosolic phospholipase A2? (cPLA2?) via production of prohypertensive eicosanoids. Since Ang II increases blood pressure (BP) via its action in the subfornical organ (SFO), it led us to investigate the expression and possible contribution of cPLA2? to oxidative stress and development of hypertension in this brain area. METHODS: Adenovirus (Ad)-green fluorescence protein (GFP) cPLA2? short hairpin (sh) RNA (Ad-cPLA2? shRNA) and its control Ad-scrambled shRNA (Ad-Scr shRNA) or Ad-enhanced cyan fluorescence protein cPLA2? DNA (Ad-cPLA2? DNA) and its control Ad-GFP DNA were transduced into SFO of cPLA2?+/+ and cPLA2??/? male mice, respectively. Ang II (700 ng/kg/min) was infused for 14 days in these mice, and BP was measured by tail-cuff and radio telemetry. cPLA2 activity, reactive oxygen species production, and endoplasmic reticulum stress were measured in the SFO. RESULTS: Transduction of SFO with Ad-cPLA2? shRNA, but not Ad-Scr shRNA in cPLA2?+/+ mice, minimized expression of cPLA2?, Ang II-induced cPLA2? activity and oxidative stress in the SFO, BP, and cardiac and renal fibrosis. In contrast, Ad-cPLA2? DNA, but not its control Ad-GFP DNA in cPLA2??/? mice, restored the expression of cPLA2?, and Ang II-induced increase in cPLA2 activity and oxidative stress in the SFO, BP, cardiac, and renal fibrosis. CONCLUSIONS: These data suggest that cPLA2? in the SFO is crucial in mediating Ang II-induced hypertension and associated pathogenesis. Therefore, development of selective cPLA2? inhibitors could be useful in treating hypertension and its pathogenesis. äBrain Cytosolic Phospholipase A2? 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